Objective: To investigate the mechanism of delaying the senescence of human diploid fibroblast (2BS) by total flavone of Ginkgo biloba (FG).
Methods: The drug sera of FG was used to treat the 2BS. The population doublings of 2BS cells were observed, the mRNA expression of P16 gene was determined by fluorescence real-time quantitative PCR.
Results: FG significantly extended the population doublings of 2BS cells, and decreased the expression of P16 mRNA.
Conclusion: FG can delay the senescence of cells by inhibiting the P16 gene expression.
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