The association of two cholesterol ester transfer protein (CETP) polymorphisms, D442G and TAQIB (B1-->B2), with high-density lipoprotein (HDL) levels in 932 Chinese obese individuals (BMI >or= 27) was investigated in comparison with normal controls (BMI

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2009.138DOI Listing

Publication Analysis

Top Keywords

cetp polymorphisms
8
hdl levels
8
chinese obese
8
association cetp
4
polymorphisms hdl
4
levels chinese
4
obese population
4
population association
4
association cholesterol
4
cholesterol ester
4

Similar Publications

Single nucleotide polymorphisms (SNPs) have been associated with the development of cardiovascular diseases (CVDs). This study correlated eight SNPs with the risk factors of CVD in a black elderly population. Genotyping was used to detect eight polymorphisms; rs675 (ApoA-IV), rs699 (Angiotensinogen (AGT)), rs247616 and rs1968905 (Cholesteryl ester transfer protein (CETP)), rs1801278 (Insulin receptor substrate 1 (IRS-1)), rs1805087 (Methylenetetrahydrofolate reductase (MTHFR)) and rs28362286 and rs67608943 (Proprotein convertase subtilisin/kexin type 9 (PCSK9)), as well as their genotypes in deoxyribonucleic acid (DNA) extracted from peripheral blood.

View Article and Find Full Text PDF
Article Synopsis
  • - Type 2 diabetes mellitus (T2DM) significantly impacts the quality of life for many Filipinos, with genetic factors contributing to 30-70% of the disease risk.
  • - This study examined the genetic variants linked to T2DM among Filipinos by comparing 66 individuals with diabetes to 121 without, identifying nine significant genetic variants tied to glucose and energy metabolism.
  • - Key variants, particularly CDKAL1 (rs7766070), show the highest risk levels, suggesting their potential use as markers for early detection and prevention of T2DM in the Filipino population.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how genetic variations in lipid-lowering drug targets relate to the prognosis of ischemic stroke patients, highlighting a previously unclear area.
  • It identifies specific gene variants (rs2006760-C, rs11206510-T, rs1864163-G, and rs9929488-G) that are linked to a higher likelihood of death or major disability within two years after a stroke.
  • The research concludes that a higher genetic risk score, calculated from these variants, is associated with an increased risk of adverse outcomes, making it a potential predictor for stroke prognosis.
View Article and Find Full Text PDF

Interaction of CETP rs708272 Polymorphism on Trans Fatty Acid Intake and Glucose Metabolism Markers.

Nutrients

October 2024

Laboratorio Nacional de Investigación para la Inocuidad Alimentaria (LANIIA)-Unidad Nayarit, Universidad Autónoma de Nayarit, Tepic 63173, Mexico.

Dietary fats influence gene expression and several metabolic pathways. Therefore, it is crucial to study the role of personal genotypes in the interaction between fat consumption and cardiometabolic markers. This research aimed to determine the interaction of the rs708272 polymorphism of and the fatty acid intake with changes in the HOMA-IR in adults living with overweight or obesity.

View Article and Find Full Text PDF
Article Synopsis
  • The study aims to find genetic factors that contribute to myopic macular neovascularization (mMNV) in people with severe myopia through a genome-wide association study (GWAS) meta-analysis.
  • Researchers analyzed data from 2,783 highly myopic individuals, including 608 with mMNV and 2,175 controls, using advanced genetic analysis techniques.
  • The study discovered a new genetic variant, rs56257842, associated with a lower risk of mMNV, and found that certain transcription factors interacted differently with this variant, suggesting it plays a significant role in the disease's development.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!