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Translation of the downstream ORF from bicistronic mRNAs by human cells: Impact of codon usage and splicing in the upstream ORF.
Protein Sci
February 2025
Laboratory MIVEGEC (Univ. Montpellier, CNRS, IRD), French National Center for Scientific Research (CNRS), Montpellier, France.
Biochemistry textbooks describe eukaryotic mRNAs as monocistronic. However, increasing evidence reveals the widespread presence and translation of upstream open reading frames preceding the "main" ORF. DNA and RNA viruses infecting eukaryotes often produce polycistronic mRNAs and viruses have evolved multiple ways of manipulating the host's translation machinery.
View Article and Find Full Text PDFEnhancing home-based physical activity for neurodivergent children: adapting the program with AI and universal design.
Front Physiol
January 2025
School of Kinesiology, University of Michigan, Ann Arbor, MI, United States.
Purpose: While it is common practice for schools across the United States to include neurodivergent children in physical education classes, many programs outside of school-such as those at home or in the community-are not effectively tailored to meet their support needs. This gap contributes to lower levels of physical activity among neurodivergent children. Our objective was to address this issue by systematically adapting the program to enable neurodivergent children to safely engage in physical activity at home.
View Article and Find Full Text PDFRegistered Nurses' Experience of Person-Centred Care Through Digital Aids in Primary Care Setting During the COVID-19 Pandemic.
Nurs Open
January 2025
Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.
Aim: The aim of this study was to describe registered nurses' experience of person-centred care through digital media during the COVID-19 pandemic. The first wave of COVID-19 took healthcare services worldwide by surprise and affected all levels of care. Registered nurses within primary care settings had to adjust to new meeting forums with patients and in collaborations with other organisations to transfer patients from hospital to home care in a safe and secure manner using digital aids.
View Article and Find Full Text PDFDetermining the risk factors of malaria and anemia in children between 6 and 59 months using the joint generalized linear mixed model on the 2021 Nigeria Malaria Indicator Survey dataset.
Front Public Health
January 2025
School of Mathematics, Statistics, and Computer Science, University of Kwazulu-Natal, Pietermaritzburg, South Africa.
Background: Malaria and anemia are significant public health concerns that contribute to child mortality in African. Despite global efforts to control the two diseases, their prevalence in high-risk regions like Nigeria remains high. Understanding socioeconomic, demographic, and geographical factors associated with malaria and anemia, is critical for effective intervention strategies.
View Article and Find Full Text PDFEvaluating access to psychosocial services for the medicaid-insured children in Georgia.
BMC Public Health
January 2025
Georgia Institute of Technology, H. Milton Stewart School of Industrial and Systems Engineering, 755 Ferst Dr NW, Atlanta, 30332, Georgia.
Background: Evaluating access to psychosocial services can inform policy decision-making on ways to address shortages in the availability of mental health (MH)-specialized providers. The objective of the study was to assess how the mental health (MH)-specialized workforce met the demand for psychosocial services of Medicaid-insured children in Georgia, with direct relevance in establishing quantitative network adequacy.
Methods: We used the 2018 Medicaid (TAF) claims data, the 2018 National Plan and Provider Enumeration System database, and the 2019 Georgia school-based program data to estimate community-level demand and practice-level supply of psychosocial services.
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