AI Article Synopsis
- Three types of protein-metal complexes were created to serve as pH sensing devices in aqueous solutions.
- These complexes, derived from biological proteins transferrin and lactoferrin, showed stable luminescence properties, particularly with long-lasting green signals that altered based on pH levels.
- The development of these pH-responsive devices involved using biologically derived components and luminescent lanthanide ions, allowing for effective monitoring of pH changes even in challenging chemical environments.
Article Abstract
Three kinds of protein-metal complexes were developed as pH sensing devices in the aqueous solutions. Biological transferrin and lactoferrin proteins formed stable Tb3+ complexes, which exhibited long-lived and green luminescence signals. They showed pH-dependent luminescence changes around neutral pH, coupled with their Tb3+ complexation/decomplexation. Since fluorescein-labeled transferrin-Fe3+ complex exhibited fluorescence changes at lower pH, these three protein complexes covered wide pH-responsive ranges. The immobilized biotinylated transferrin-Tb3+ complexes on the micrometer-scaled bead also operated as a pH-responsive luminescent indicator. Since the transferrin ligand had rapid Tb3+ complexation/decomplexation process, its Tb3+ complex exhibited pH-responsive luminescence signals even in the presence of Fe3+ cation. A new series of tunable luminescent pH sensing devices were developed by combination of biological protein and luminescent lanthanide center.
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| http://dx.doi.org/10.1166/jnn.2009.j080 | DOI Listing |
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