AI Article Synopsis
- A new cholesteryl-cyclodextrin derivative was developed for making nanocapsules, which are tiny carriers for drugs.
- The structure of this derivative, named Chol-betaCD-Ac, was analyzed using advanced NMR technology.
- The nanocapsules successfully encapsulated vitamin A propionate, a poorly soluble drug, enabling stable and consistent size distribution, and facilitating better skin penetration.
Article Abstract
A new cholesteryl-cyclodextrin derivative, obtained by grafting a single cholesterol on a cyclodextrin, was proved suitable for the manufacture of nanocapsules. The chemical structure of Chol-betaCD-Ac was assessed using high resolution 1H-NMR. These nanocapsules were loaded with a lipophilic drug, i.e., vitamin A propionate (PRVA) which is a highly unstable and poorly water soluble molecule with a real interest in therapeutic. The oily nature of vitamin A propionate leads to the formation of nanocapsules with a reproductible size distribution and a long term stability. The colloidal suspension can be used to form a gel which allow to achieve penetration in the skin of the PRVA encapsulated.
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| http://dx.doi.org/10.1166/jnn.2009.j094 | DOI Listing |
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