AI Article Synopsis
- The GLW-amide family is a group of neuropeptides found in cnidarian species, defined by a specific C-terminal amino acid sequence.
- Researchers investigated rat brains using an anti-GLW-amide antibody and discovered GLW-amide-like immunoreactivity in certain brain regions, particularly the laterodorsal tegmental nucleus and the pedunculopontine tegmental nucleus.
- The findings suggest the presence of unknown GLW-amide-like peptides in the rat nervous system, indicating that GLW-amide-LI can serve as a marker for neural projections from certain cholinergic neurons.
Article Abstract
The GLW-amide family is a neuropeptide family found in cnidarian species and is characterized by the C-terminal amino acid sequence -Gly-Leu-Trp-NH(2). To detect mammalian peptides structurally related to the GLW-amide family, we examined rat brain by immunohistochemistry with an anti-GLW-amide antibody. GLW-amide-like immunoreactivity (GLW-amide-LI) was observed in thin varicose fibers in some regions of the brain. Most neurons showing GLW-amide-LI were observed in the laterodorsal tegmental nucleus, pedunculopontine tegmental nucleus, and trigeminal/spinal ganglia. These results strongly suggest that the rat nervous system contains as yet unidentified GLW-amide-like peptides, and that GLW-amide-LI in the brain is a good marker for ascending projections from mesopontine cholinergic neurons.
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| http://dx.doi.org/10.1007/s00441-009-0808-8 | DOI Listing |
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