Background: Heat shock proteins (HSPs) are a group of highly immunogenic proteins with an exceptional degree of conservation. Cells or tissues from a wide range of tumors have been shown to express atypical levels of 1 or more HSPs. Experimental evidence suggests that HSPs may promote tumorigenesis by suppressing apoptosis.
Aim: The aim of this investigation was to study the expression and the localization of HSP70 in oral squamous cell carcinoma (OSCC) and to compare HSP70 expression between neoplastic, dysplastic lesions and normal oral tissues.
Methods: Immunohistochemistry staining was conducted to study HSP70 expression in 50 paraffinized tissue samples: 30 OSCCs, 10 leukoplakias with dysplasia and 10 samples from normal oral tissue.
Results: Our results showed that all slides with OSCC intensely expressed HSP70. Dysplastic lesions were positive to a lesser extent for HSP70. Samples from normal oral tissue were all negative for HSP70.
Conclusions: It is concluded that increased HSP70 immunoexpression could be a marker for the presence of epithelial dysplasia or epithelial malignant transformation.
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