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RipE expression correlates with high ATP levels in , which confers resistance during the extracellular stage to facilitate a new cycle of infection.
Front Cell Infect Microbiol
October 2024
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Ehrlichiosis is a potentially life-threatening disease caused by infection with the obligatory intracellular bacteria species. infection of mice provides an animal model of ehrlichiosis as it recapitulates full-spectrum and lethal ehrlichiosis in humans. The transposon mutant of , which encodes a previously uncharacterized hypothetical protein, is attenuated in both infection and virulence in mice.
View Article and Find Full Text PDFLong-Term Protective Immunity against Infection Induced by a Genetically Modified Live Vaccine.
Vaccines (Basel)
August 2024
Center of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
Human monocytic ehrlichiosis, an emerging tick-borne disease, is caused by . Infections with the pathogen are also common in the canine host. Our previous studies demonstrated that functional disruption within the phage head-to-tail connector protein gene results in bacterial attenuation, creating a modified live attenuated vaccine (MLAV).
View Article and Find Full Text PDFHepatocyte-specific regulation of autophagy and inflammasome activation via MyD88 during lethal infection.
Front Immunol
December 2023
Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Hepatocytes play a crucial role in host response to infection. is an obligate intracellular bacterium that causes potentially life-threatening human monocytic ehrlichiosis (HME) characterized by an initial liver injury followed by sepsis and multi-organ failure. We previously showed that infection with highly virulent () induces liver damage and fatal ehrlichiosis in mice via deleterious MyD88-dependent activation of CASP11 and inhibition of autophagy in macrophage.
View Article and Find Full Text PDFEvasion of host antioxidative response via disruption of NRF2 signaling in fatal Ehrlichia-induced liver injury.
PLoS Pathog
November 2023
Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America.
Ehrlichia is Gram negative obligate intracellular bacterium that cause human monocytotropic ehrlichiosis (HME). HME is characterized by acute liver damage and inflammation that may progress to fatal toxic shock. We previously showed that fatal ehrlichiosis is due to deleterious activation of inflammasome pathways, which causes excessive inflammation and liver injury.
View Article and Find Full Text PDFMultiple genes critical for persistent infection in a vertebrate host are identified as nonessential for its growth in the tick vector; .
Front Cell Infect Microbiol
July 2023
Center of Excellence for Vector-Borne Diseases, Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States.
is a tick-transmitted monocytic ehrlichiosis agent primarily causing the disease in people and dogs. We recently described the development and characterization of 55 random mutations in , which aided in defining the critical nature of many bacterial genes for its growth in a physiologically relevant canine infection model. In the current study, we tested 45 of the mutants for their infectivity ability to the pathogen's tick vector; .
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