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Recent progress in the organoselenium-catalyzed difunctionalization of alkenes.
Org Biomol Chem
January 2025
School of Pharmacy, Nantong Key Laboratory of Small Molecular Drug Innovation and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226019, People's Republic of China.
Selenium-based catalysts have recently been utilized to facilitate a variety of new organic transformations, owing to their intrinsic advantages, including low cost, low toxicity, stability in both air and water, and strong compatibility with diverse functional groups. The difunctionalization of alkenes-the process of incorporating two functional groups onto a carbon-carbon double bond-has garnered particular interest within the chemical community owing to its significant applications in organic synthesis. Recently, organoselenium-catalyzed difunctionalization of alkenes has emerged as an ideal and powerful route to obtain high-value vicinal difunctionalized molecules.
View Article and Find Full Text PDFGlobal Aromatic Ring Currents in Neutral Porphyrin Nanobelts.
ACS Nano
January 2025
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.
The ability of a ring-shaped molecule to sustain a global aromatic or antiaromatic ring current when placed in a magnetic field indicates that its electronic wave function is coherently delocalized around its whole circumference. Large molecules that display this behavior are attractive components for molecular electronic devices, but this phenomenon is rare in neutral molecules with circuits of more than 40 π-electrons. Here, we use theoretical methods to investigate how the global ring currents evolve with increasing ring size in cyclic molecular nanobelts built from edge-fused porphyrins.
View Article and Find Full Text PDFDiketopiperazine/piperidine alkaloid as a potential broad-spectrum coronaviral entry inhibitor identified by supercomputer-based virtual screening from a large natural product-based library.
Biomed Pharmacother
January 2025
Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany. Electronic address:
The COVID-19 pandemic has underscored the urgent need for antiviral agents capable of targeting a broad range of coronaviruses, including emerging variants of SARS-CoV-2. While vaccines have been pivotal, the search for drugs that can prevent viral entry into host cells remains crucial, especially against evolving viral forms and other coronaviruses. In this study, we investigated natural products as a source of antiviral agents, focusing on their potential to block the spike protein's receptor-binding domain (RBD).
View Article and Find Full Text PDFRecent Advances on Characterization Techniques for the Composition-Structure-Property Relationships of Solid Electrolyte Interphase.
Small Methods
January 2025
College of Physics and Energy, Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials, Fujian Normal University, Fuzhou, 350117, China.
The Solid Electrolyte Interphase (SEI) is a nanoscale thickness passivation layer that forms as a product of electrolyte decomposition through a combination of chemical and electrochemical reactions in the cell and evolves over time with charge/discharge cycling. The formation and stability of SEI directly determine the fundamental properties of the battery such as first coulombic efficiency (FCE), energy/power density, storage life, cycle life, and safety. The dynamic nature of SEI along with the presence of spatially inhomogeneous organic and inorganic components in SEI encompassing crystalline, amorphous, and polymeric nature distributed across the electrolyte to the electrolyte-electrode interface, highlights the need for advanced in situ/operando techniques to understand the formation and structure of these materials in creating a stable interface in real-world operating conditions.
View Article and Find Full Text PDFClay-catalyzed ozonation of Norfloxacin - Effects of metal cation and degradation rate on aqueous media toxicity towards Lemna minor.
Chemosphere
January 2025
Nanoqam, Department of Chemistry, University of Quebec at Montreal, H3C 3P8, Canada; École de technologie supérieure, Montréal (Québec), Canada, H3C 1K3. Electronic address:
Article Synopsis
- Norfloxacin was ozonized in clay suspensions to study its toxicity on Lemna minor, which helps assess antibiotic impact in environments with clay.
- The study found that norfloxacin causes toxicity in Lemna minor through oxidative stress, worsened by ozonation, affecting growth and chlorophyll levels.
- Results indicate that the type of clay catalyst and the oxidation process influence the toxicity outcomes, revealing the potential formation of more harmful byproducts from the antibiotic.
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