Impact of cigarette smoking in type 2 diabetes development.

Acta Pharmacol Sin

Center for Metabolic Biology, Arizona State University, Tempe, AZ 85287-3704, USA.

Published: June 2009

AI Article Synopsis

  • Many patients with type 2 diabetes are at risk for serious complications, especially if they are heavy smokers.
  • Cigarette smoking not only raises the risk of developing type 2 diabetes but also exacerbates its effects, largely due to nicotine.
  • Recent studies highlight how nicotine negatively affects insulin action and secretion, which contributes to the progression of type 2 diabetes.

Article Abstract

Many patients with type 2 diabetes mellitus (DM2) are at risk for micro and macro vascular complications, which could be observed in heavy smokers. Cigarette smoking increases the risk for type 2 diabetes incidence. Nicotine, acknowledged as the major pharmacologically active chemical in tobacco, is responsible for the association between cigarette smoking and development of diabetes. This minireview summarized recent studies on nicotine effects on insulin action and insulin secretion, indicating the impact of nicotine on type 2 diabetes development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002374PMC
http://dx.doi.org/10.1038/aps.2009.49DOI Listing

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