AI Article Synopsis
- Streptococcus pneumoniae sortase A (SrtA) is a vital enzyme linked to the bacteria's ability to stick and colonize, and it's conserved across different strains.
- Mice immunized with recombinant SrtA showed significant protection against infection when challenged with S. pneumoniae, both through direct immunization and by transferring immune serum.
- The study suggests that SrtA could be a promising target for a new, protein-based vaccine against pneumonia, as it reduced severe infection in mice without affecting nasopharynx colonization.
Article Abstract
Streptococcus pneumoniae sortase A (SrtA) is a transpeptidase that is highly conserved among pneumococcal strains, whose involvement in adhesion/colonization has been reported. We found that intraperitoneal immunization with recombinant SrtA conferred to mice protection against S. pneumoniae intraperitoneal challenge and that the passive transfer of immune serum before intraperitoneal challenge was also protective. Moreover, by using the intranasal challenge model, we observed a significant reduction of bacteremia when mice were intraperitoneally immunized with SrtA, while a moderate decrease of lung infection was achieved by intranasal immunization, even though no influence on nasopharynx colonization was seen. Taken together, our results suggest that SrtA is a good candidate for inclusion in a multicomponent, protein-based, pneumococcal vaccine.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708569 | PMC |
| http://dx.doi.org/10.1128/IAI.01516-08 | DOI Listing |
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