This article develops a latent model and likelihood-based inference to detect temporal clustering of events. The model mimics typical processes generating the observed data. We apply model selection techniques to determine the number of clusters, and develop likelihood inference and a Monte Carlo expectation-maximization algorithm to estimate model parameters, detect clusters, and identify cluster locations. Our method differs from the classical scan statistic in that we can simultaneously detect multiple clusters of varying sizes. We illustrate the methodology with two real data applications and evaluate its efficiency through simulation studies. For the typical data-generating process, our methodology is more efficient than a competing procedure that relies on least squares.
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http://dx.doi.org/10.1111/j.1541-0420.2009.01197.x | DOI Listing |
J Breath Res
January 2025
School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Rd, Qingdao, Shandong, 266003, CHINA.
Lung cancer is one of the most common malignancy in the world, and early detection of lung cancer remains a challenge. The exhaled breath condensate (EBC) from lung and trachea can be collected totally noninvasively. In this study, our aim is to identify differential metabolites between non-small cell lung cancer (NSCLC) and control EBC samples and discriminate NSCLC group from control group by orthogonal projections to latent structures-discriminant analysis (OPLS-DA) models.
View Article and Find Full Text PDFPLoS One
January 2025
National Institute of Public Health, University of Southern Denmark, Copenhagen K, Denmark.
Latent transition analysis (LTA) is a useful statistical modelling approach for describe transitions between latent classes over time. LTA may be characterized in terms of prevalence at each time point and through transition probabilities over time. Investigating predictors of these transitions is often of key interest.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
School of Psychological Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW 2308, Australia.
Self-reports are used ubiquitously to probe people's thoughts, feelings, and behaviors and inform medical decisions, enterprise operations, and government policy and legislation. Despite their pervasive use, self-report measures such as Likert scales have a profound problem: Standard analytic approaches do not control for the confounding effects of idiosyncratic response biases. Here, we present a model-based solution to this problem.
View Article and Find Full Text PDFAnn Med
December 2025
Department of Nursing, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Introduction: Multimorbidity is increasing globally, emphasizing the need for effective self-management strategies. The Cumulative Complexity Model (CuCoM) offers a unique perspective on understanding self-management based on workload and capacity. This study aims to validate the CuCoM in multimorbid patients and identify tailored predictors of self-management.
View Article and Find Full Text PDFBiostat Epidemiol
October 2024
Department of Epidemiology and Biostatistics, Indiana University, Bloomington, Indiana, US.
Wearable devices enable the continuous monitoring of physical activity (PA) but generate complex functional data with poorly characterized errors. Most work on functional data views the data as smooth, latent curves obtained at discrete time intervals with some random noise with mean zero and constant variance. Viewing this noise as homoscedastic and independent ignores potential serial correlations.
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