The comparative analysis of the phospholipid composition and the physics-chemical characteristics of the spleen, blood erythrocytes and liver lipids of wild rodents of different age (Microtus oeconomus Pall.) was carried out. The interrelation between the age changes of the phospholipid composition in spleen and/or the antiperoxide activity and the content of peroxides in lipids was shown. The scale and direct of the age changes of the phospholipid composition depend on the tissue type, basic level of the lipid antioxidative activity and the animal sex. The scale of the age changes of studied parameters is modified by population factors.

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