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Minimal methimazole exposure-induced fatal pancytopenia.
BMJ Case Rep
January 2025
Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
This case highlights that refractory pancytopenia leading to death can occur with methimazole treatment even at a very low cumulative dose and after a very short duration of exposure. In addition, the standard treatments to correct the pancytopenia may not be effective and a bone marrow transplant may be required. Current American Thyroid Association guidelines do not recommend routine monitoring of the complete blood count in patients receiving thionamides because of the rapidity of the onset of agranulocytosis and the lack of positive evidence that such monitoring would be useful.
View Article and Find Full Text PDFMicroplastics in Cuban freshwaters: diversity, temporal changes, and effects on extracellular enzymatic activity.
Environ Pollut
January 2025
Universidad de Alcalá, Departamento de Química Analítica, Química Física e Ingeniería Química, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain.
Plastics, as synthetic polymers, are emerging contaminants that can harm organisms and ecosystems. This study investigates the presence of microplastics in sediments of two rivers in western Cuba, assessing their temporal variability, diversity, and characterizing the types of microplastics in these ecosystems. Additionally, the study examines the relationship between microplastic concentrations, the extracellular enzymatic activity of benthic microbial communities, and nutrient levels in sediments.
View Article and Find Full Text PDFRegulatory issues surrounding the management of selenium-introduction to a special series of papers.
Integr Environ Assess Manag
January 2025
International Institute for Sustainable Development-Experimental Lakes Area, Winnipeg, Manitoba, Canada.
Selenium (Se) is a naturally occurring metalloid in soils and rocks that is released by weathering processes; it is also enriched by some anthropogenic activities, including mining and agriculture. The mechanism of Se aquatic toxicity has been understood for several decades; at elevated concentrations, dietary Se can accumulate in maternal tissues of fish and birds, become deposited into their eggs, and can potentially result in impaired embryological development. North American environmental regulations have acknowledged differences in species sensitivity and variation among aquatic environments (i.
View Article and Find Full Text PDFWater quality plays a critical role in health care, particularly in the processing of medical devices. This article highlights the infection control risks associated with water sources and the regulatory requirements for water management plans in health care facilities. The guidance on water quality has evolved from the initial technical information report provided by the Association for the Advancement of Medical Instrumentation in 2014 to the more recent 2023 publication of the American National Standards Institute and Association for the Advancement of Medical Instrumentation standard for water used in medical device processing.
View Article and Find Full Text PDFUser-Centered Design of Neuroprosthetics: Advancements and Limitations.
CNS Neurol Disord Drug Targets
January 2025
Biosciences and Bioengineering PhD Program, American University of Sharjah, UAE.
Neurological conditions resulting from severe spinal cord injuries, brain injuries, and other traumatic incidents often lead to the loss of essential bodily functions, including sensory and motor capabilities. Traditional prosthetic devices, though standard, have limitations in delivering the required dexterity and functionality. The advent of neuroprosthetics marks a paradigm shift, aiming to bridge the gap between prosthetic devices and the human nervous system.
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