Aim Of The Study: The aim of the study was to evaluate the antihyperglycaemic activity of aqueous (PPSB-AQE) and petroleum ether (PPSB-PEE) extract of stem bark Pongamia pinnata in alloxan induced diabetic mice.
Materials And Methods: Diabetes was induced in mice by alloxan (80 mg/kg, i.v.). After acute and subacute treatment serum glucose was determined. OGTT was performed in PPSB-PEE pretreated animals.
Results: PPSB-PEE (25, 50, 100, 200 and 400mg/kg) showed significant reduction in serum glucose level in acute and subacute studies. The antihyperglycaemic effects of PPSBPE (100, 200 and 400mg/kg) showed onset at 2h and peak effect at 6h and the effect was sustained until 24 th h with 400mg/kg. In subacute study, antihyperglycaemic effect was observed on 21st day. In PPSBPE treated mice the body weight was not reduced in contrast to that in vehicle group. In OGTT, increased glucose utilization was observed.
Conclusions: It is concluded that PPSB-PEE but not PPSB-AQE showed antihyperglycaemic activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2009.02.018 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation.
Mol Metab
January 2025
Section of Endocrinology and Investigative Medicine, Imperial College London, United Kingdom. Electronic address:
Objectives: There is renewed interest in targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) for treatment of obesity and type 2 diabetes. G-protein coupled receptor desensitisation is suggested to reduce the long-term efficacy of glucagon-like-peptide 1 receptor (GLP-1R) agonists and may similarly affect the efficacy of GIPR agonists. We explored the extent of pancreatic GIPR functional desensitisation with sustained agonist exposure.
View Article and Find Full Text PDFIntense simplified strategy for newly diagnosed type 2 diabetes in patients with severe hyperglycaemia: multicentre, open label, randomised trial.
BMJ
October 2024
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China
Objective: To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long term glycaemic outcomes in patients with newly diagnosed type 2 diabetes mellitus and severe hyperglycaemia.
Design: Multicentre, open label, randomised trial.
Setting: 15 hospitals in China between December 2017 and December 2020.
Unintentional poisoning in older Australians: a retrospective audit of New South Wales Poisons Information Centre data.
Clin Toxicol (Phila)
October 2024
Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital Sydney, Australia.
Introduction: Poisons information centres provide phone-based risk assessment and management advice on poisonings. Unintentional poisonings are a common reason for consulting a poisons information centre, and older adults are at increased risk of unintentional poisoning and adverse outcomes. We describe patterns of unintentional poisoning in older adults reported to a regional poisons information centre.
View Article and Find Full Text PDFBibliometric, taxonomic, and medicinal perspectives of Imazeki: A mini review.
Mycology
January 2024
Department of Biomedical Sciences, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
, a traditional medicine in Asian countries, has been used to prevent and treat various ailments for centuries. (synonym ), also known as purple Lingzhi, is a species that is currently underutilised when compared to (Lingzhi). However, in recent decades, this mushroom has garnered significant attention due to its ethnomedicinal uses, especially in Southeast Asia regions like Malaysia.
View Article and Find Full Text PDFImeglimin for Type 2 Diabetes Mellitus: Its Efficacy and Insight Into the Potential Benefit for Renal and Liver Function.
Cureus
August 2024
Department of Nephrology, National Defense Medical College, Tokorozawa, JPN.
Article Synopsis
- * A study involving ten patients examined the drug's efficacy over six months, finding a significant reduction in HbA1c levels from 8.1% to 6.9%, indicating improved blood sugar control.
- * The study also noted no negative impact on kidney function and some improvement in liver conditions, suggesting overall health benefits; however, more research is needed to assess its long-term effects.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!