Changes in vital functions in endotoxicosis were appraised in 41 patients with acute peritonitis during stages of intensive therapy in a complex fashion. Correlative relations were revealed between the severity of endotoxicosis and the function of blood circulation, blood gases, and respiration. Endotoxicosis was characterized by increased level of middle mass molecules, circulating immune complexes, leukocytic index of intoxication, asparagate and alanine transferase. Hemodynamics functioned in hyperdynamic regimen in the reactive stage of peritonitis, in the normodynamic regimen in the transitional stage, and in the hypodynamic regimen in the toxic stage. The immune status was inhibited in the toxic stage of peritonitis. Normalization of vital functions in the postoperative period occurred in parallel with decrease of the severity of endotoxicosis. The studied values approximated the average-age indices in patients with the toxic stage of peritonitis by postoperative days 7-10; sorption methods of detoxification were included in the complex intensive therapy measures in these children.
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