Besides being an important component of spices used worldwide, capsaicin has wide-ranging therapeutic potential as a hypolipidemic, antioxidant and anti-inflammatory agent. Accordingly, it is very important to investigate the long-term effect of capsaicin in the pathogenesis of Alzheimer's disease. In this study, the effects of capsaicin on the processing of amyloid precursor protein (APP) were investigated in an in vivo model. The APP mRNA and protein levels were examined in the brain cortices of control and capsaicin-treated rats. The protein kinase C (PKC) translocation state in the soluble and membrane-bound fractions and the levels of beta-secretase (BACE) were also evaluated. Capsaicin enhanced the level of membrane-bound APP 1.7-fold. The APP mRNA and PKC and BACE protein levels were unchanged after capsaicin treatment. These in vivo data indicate that capsaicin is able to interfere with the brain APP metabolism by promoting the amyloidogenic route. We suggest that PKC is not involved in the mechanism underlying the effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuint.2009.01.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-Site Red-Edge Excitation Shift Reveals the Residue-Specific Solvation Dynamics during the Native to Amyloid-like Transition of an Amyloidogenic Protein.
J Phys Chem B
December 2024
Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
Changes in water-protein interactions are crucial for proteins to achieve functional and nonfunctional conformations during structural transitions by modulating local stability. Amyloid-like protein aggregates in deteriorating neurons are hallmarks of neurodegenerative disorders. These aggregates form through significant structural changes, transitioning from functional native conformations to supramolecular cross-β-sheet structures via misfolded and oligomeric intermediates in a multistep process.
View Article and Find Full Text PDFThe assessment of pharmacokinetics and neuroprotective effect of berberine hydrochloride-embedded albumin nanoparticles via various administration routes: comparative studies in rats.
J Microencapsul
November 2024
Department of Pharmaceutics, Zagazig University, Zagazig, Egypt.
The current study aimed to evaluate the pharmacokinetics and neuroprotective effect of well-characterised berberine-bovine serum albumin (BBR-BSA) nanoparticles. BBR-BSA nanoparticles were generated by desolvation method. Entrapment efficiency, loading capacity, particle size, polydispersity index, surface morphology, thermal stability, and release were estimated.
View Article and Find Full Text PDFCatalytic Nanomaterials by Conjugation of an Artificial Heme-Peroxidase to Amyloid Fibrils.
ACS Appl Mater Interfaces
August 2024
Department of Chemical Sciences, University of Naples Federico II, via Cintia 21, 80126 Naples, Italy.
The self-assembly of proteins and peptides into fibrillar amyloid aggregates is a highly promising route to define the next generation of functional nanomaterials. Amyloid fibrils, traditionally associated with neurodegenerative diseases, offer exceptional conformational and chemical stability and mechanical properties, and resistance to degradation. Here, we report the development of catalytic amyloid nanomaterials through the conjugation of a miniaturized artificial peroxidase (FeMC6*a) to a self-assembling amyloidogenic peptide derived from human transthyretin, TTR(105-115), whose sequence is YTIAALLSPYS.
View Article and Find Full Text PDFPotential neuroprotective benefits of plant-based fermented foods in Alzheimer's disease: an update on preclinical evidence.
Food Funct
April 2024
Department of Food Science and Engineering, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518060, China.
Article Synopsis
- Alzheimer's disease (AD) currently has no effective treatments, prompting research into prevention methods, particularly through plant-based fermented foods.
- This study systematically reviewed preclinical research on the neuroprotective effects of these foods on AD, analyzing 25 reports for factors like animal models, dosages, and outcome measures.
- Results suggest that plant-based fermented foods may improve cognitive function and reduce neurodegeneration in AD, but the limited number of studies and their moderate quality highlight the need for more rigorous research.
AmyloComp: A Bioinformatic Tool for Prediction of Amyloid Co-aggregation.
J Mol Biol
September 2024
Centre de Recherche en Biologie Cellulaire de Montpellier, CNRS, Université Montpellier, Montpellier 34293, France. Electronic address:
Article Synopsis
- Amyloid fibrils usually consist of multiple copies of the same protein arranged in a specific structure, but recent studies show that different proteins can also co-aggregate to form mixed amyloid structures.
- Co-aggregation is significant because it affects the infectivity of amyloids and the mechanisms behind functional amyloids, prompting researchers to analyze its structural characteristics more closely.
- A new computational method has been developed to predict which amyloidogenic proteins can stack together, and this study included a dataset of known protein pairs to improve the algorithm, potentially aiding in identifying proteins that could trigger amyloidosis in humans.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!