Prism adaptation has received much attention in recent years as a potential method for the rehabilitation of visual neglect. Recent theories as to the underlying mechanisms include oculomotor resetting and pathological realignment of subjective straight ahead (SSA). Typical prism adaptation procedures involve both ocular rotation and manual correction making the precise mechanisms and contribution of these to the amelioration of neglect difficult to determine. This experiment separated the contributions of ocular rotation and manual error reduction to SSA realignment in normal participants by shifting the eye alone, the hand alone or both together. Rotating the eye alone did not contribute to SSA realignment whereas shifting the hand did.
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Background: Underutilization of medications for opioid use disorder (MOUD), which reflects the limited number of patients initiating treatment and being retained in treatment, remains a persistent barrier to addressing the opioid epidemic. Using an adapted PRISM (Practical, Robust Implementation and Sustainability Model) framework, this study describes multi-level barriers and facilitators to expanding MOUD as part of the HEALing (Helping to End Addiction Long-term) Communities Study in Kentucky (HCS-KY).
Methods: Cross-sectional small group and individual semi-structured interviews were conducted with 60 employees representing 30 MOUD agencies in eight Kentucky counties from December 2022 to June 2023.
Protocol for generating a co-culture of macrophages with breast cancer tumoroids.
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University Lille, Inserm, CHU Lille, U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse - PRISM, F-59000 Lille, France; Equipe Labellisée Ligue Contre le Cancer, Lille, France. Electronic address:
Cancer progression and treatment outcomes are heavily influenced by the tumor microenvironment (TME), especially through immune cell interactions. Here, we present a protocol for generating co-cultures of tumoroids with macrophages, either semi-liquid or Matrigel-embedded. We describe steps for macrophage preparation, co-culture establishment, and medium adjustments to support cell viability and function.
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Background Aplastic anemia (AA) is a rare and heterogeneous hematological disorder defined as pancytopenia with hypocellular bone marrow in the absence of abnormal infiltration or medullary fibrosis. Various causes of AA have been identified, such as autoimmune factors, bone marrow injuries, viral infections, and genetic disorders. The symptoms of AA are directly linked to pancytopenia and the most common are fatigue, recurrent infections, and bleeding problems.
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Mavacamten, the first drug in the class of β-cardiac myosin modulator, is used for the treatment of patients with hypertrophic cardiomyopathy. This orally administered drug demonstrates wide interpatient variability in pharmacokinetics parameters, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 poor metabolizers have increased exposure and are at increased risk of reduced cardiac hypercontractility.
View Article and Find Full Text PDFThe Application and Evolution of the Practical, Robust Implementation and Sustainability Model (PRISM): History and Innovations.
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Article Synopsis
- Implementation science theories, models, and frameworks (TMF) aim to simplify the translation of research into practice, guiding users in strategy selection and outcome evaluation.
- The Practical, Robust Implementation and Sustainability Model (PRISM) assesses key factors affecting the reach and effectiveness of health interventions and has been extensively used in over 200 publications since 2008.
- PRISM has evolved to be more accessible for non-researchers and is being used to address health equity issues while adapting to the needs of diverse settings.
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