AI Article Synopsis
- LPLs are recognized for their role as mediators through G-protein-coupled receptors, with lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) being particularly important in biological systems.
- Recent studies highlight how other LPLs, such as lysophosphatidylserine (LPS) and lysophosphatidylthreonine (LPT), exhibit mediator-like effects both in living organisms and laboratory settings, but the understanding of their exact mechanisms and roles is still limited.
- This review aims to summarize the functions of LPS, LPT, lysophosphatidylethanolamine (LPE), and lysophosphatidylglycerol (
Article Abstract
It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G-protein-coupled receptors. Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo. On the other hand, other LPLs such as lysophosphatidylserine (LPS), lysophosphatidylthreonine (LPT), lysophosphatidylethanolamine (LPE), lysophosphatidylinositol (LPI) and lysophosphatidylglycerol (LPG) have been reported to show lipid mediator-like responses both in vivo (LPS and LPT) and in vitro (LPS, LPT, LPE and LPG), while very little is known about their receptor, synthetic enzyme and patho-physiological roles. In this review, we summarize the actions of these LPLs as lipid mediators including LPS, LPT, LPE and LPG.
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| http://dx.doi.org/10.1016/j.prostaglandins.2009.04.009 | DOI Listing |
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