[Evaluation of retinal function after photodynamic therapy of subfoveal choroidal neovascularisation in patients with age-related macular degeneration].

Introduction: The aim of our study was to evaluate the visual acuity, visual field, retinal bioelectrical function and fluorescein angiography results in patients with subfoveal choroidal neovascularisation treated with photodynamic therapy (PDT).

Material And Methods: Visual acuity (Snellen chart), static perimetry (PS 30-2 W-W), mf-ERG (according to ISCEV standards) and fluorescein angiography were performed before, 3 and 6 months after initial photodynamic therapy in 20 eyes of 18 patients.

Results: There was no significant change in the average visual acuity after 3 and 6 months after PDT comparing to the initial examination, although the visual acuity improved in individual cases from 1 to 5 lines. In the static perimetry a significant increase in PSD was observed after 3 and 6 months accompanied by a slight but non-significant improvement of foveal sensitivity at the same time. There was no significant changes in mfERG after 3 and 6 months except of decrease in P1 wave latency in ring 2 (p < 0.04 after 2 months and p < 0.02 after 6 months). Decrease in CNV activity area was detected in 45% of cases in FA examination.

Conclusions: There was no significant influence ofPDT on visual outcome and macular bioelectrical function in 3 and 6 months follow-up, despite stabilization or improvement in FA findings in majority of cases.