The big "DIP"per: The preparation of both l,l-DIP and l,d-DIP (see structures) involves a complex case of double asymmetric induction in the key step of the synthesis. The differential ability of each isomer to contribute to thermoprotection in the context of a key enzyme has been assessed and both isomers of DIP are shown to possess biological activity.
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| http://dx.doi.org/10.1002/anie.200900480 | DOI Listing |
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