Unlabelled: Some patient with monofocal intraocular lens can achieve good near visual acuity with distance correction after cataract surgery. Understanding and measuring this phenomenon also called pseudoaccommodation can help to develop new technology to substitute or restore accommodation in pseudophakic eyes.
Aim: I. To measure accommodation after cataract surgery. II. To measure anterior chamber depth with Scheimpflug imaging and comparing results with standard, ultrasonic data. III. To compare anterior chamber depth data, repeatability, reproducibility and reliability with a new optical device, the anterior segment optical coherent tomography (Visante OCT) and immersion ultrasound method in phakic eyes.
Methods: I. We observed accommodation with defocusing technique, partial coherent interferometry method and measuring anterior chamber depth changing during ciliary muscle blocking. II. We measured anterior chamber depth with Pentacam and data were compared to standard ultrasonic method in phakic and pseudophakic eyes. III. We analyzed anterior chamber depth data, repeatability, reproducibility and reliability obtained by two observers using Visante OCT.
Results: I. A total accommodation amplitude of 0,83 D was observed with defocusing technique. Intraocular lens movement were negligible measured by partial coherent interferometry method using physiological accommodation stimulus. Mean movement of intraocular lens was 0.18 mm during blocking of the ciliary muscle. II. Pentacam and ultrasonic device measure the same anterior chamber depth in phakic eyes, but in pseudophakic eyes optical method measures significantly shallower anterior chamber depth. III. Anterior segment optical coherent tomography measures deeper anterior chamber depth than immersion ultrasonic device in phakic eyes.
Conclusions: Accomodation and pseudoaccommodation observed in pseudophakic eyes is hard to measure and only parts of this process can be measured with each technique. Anterior chamber depth data varies by the measuring technique. Repeatability, reproducibility and reliability of anterior chamber depth data were better with optical technique.
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http://dx.doi.org/10.1556/OH.2009.28565 | DOI Listing |
Pan Afr Med J
October 2024
Department of Ophthalmology, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Anterior segment dysgenesis exerts its influence on a diverse array of ocular structures, encompassing the cornea, iris, ciliary body, anterior chamber and lens. We present a 20-month-old boy with bilateral corneal opacity. The visual acuity (VA) was 6/480 in both eyes.
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Department of Ophthalmology, Saitama Medical Center, Saitama Medical University, Kawagoe-shi, Saitama, Japan.
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Department of Ophthalmology, Penn State University, Hershey, PA 17033, USA.
Extracellular vesicles (EVs) are lipid bilayer particles released by virtually all cells, with prominent roles in both physiological and pathological processes. The size, number, and molecular composition of released EVs correlate to the cells of origin, modulated by the cell's environment and pathologic state. The proteins, DNA, RNA, and protein cargo carried by EVs are protected by degradation, with a prominent role in targeted intercellular signaling.
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Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Shimotsuke-shi 329-0498, Tochigi, Japan.
Aflibercept and brolucizumab, two anti-VEGF agents used as intravitreal injections in ophthalmology, differ significantly in molecular weight (aflibercept-115 kDa and brolucizumab-26 kDa). Using aqueous humor samples collected after drug administration, we measured and performed a comparative analysis of pharmacokinetics and half-lives of these drugs in the human eye. Since the quantification of monoclonal antibodies (mAbs) using antigen-antibody reactions, such as ELISA, is influenced by endogenous ligands or anti-drug antibodies, we employed nano-surface and molecular-orientation limited proteolysis (nSMOL), combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS), for accurate measurements.
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Cardiovascular Institute "Dedinje", 111040 Belgrade, Serbia.
Coronary artery fistulas (CAFs) are rare congenital anomalies, presenting in 0.05-0.9% of cases, characterized by an aberrant connection between a coronary artery and a cardiac chamber or great vessel.
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