AI Article Synopsis
- The research introduces a new method for separating enantiomers through diastereomeric derivatives involving three stereogenic centers.
- This method utilizes a unique approach with an unstable stereogenic nitrogen that helps align the stereochemistry of the products.
- The promising results indicate that this technique has practical applications and warrants more in-depth investigation.
Article Abstract
This work has demonstrated that a previously unexplored approach to separation of enantiomers via formation of diastereomeric derivatives with three stereogenic centers has obvious practical potential and deserves further systematic study. The design reported here is based on the unusual application of a configurationally unstable stereogenic nitrogen, which plays a key role in setting up the stereochemical match between the three stereogenic centers in the corresponding products.
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| http://dx.doi.org/10.1021/ja9026055 | DOI Listing |
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