Polysubstituted 2-carboxylate and 2-phosphonate pyrroles are prepared by aromatization of the corresponding 3-oxo 2-carboxylate and 2-phosphonate NH-pyrrolidines using air. Reaction of electrophiles with 3-oxo pyrrolidine dianions readily introduces substituents, regioselectively at C-4 in these pyrrolidines.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391011PMC
http://dx.doi.org/10.1016/j.tet.2008.02.102DOI Listing

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