Purpose: To describe amyloidosis-associated neurotrophic keratopathy.
Methods: In this interventional case report, we describe the clinical findings of a patient with amyloidosis-associated neurotrophic keratopathy, precipitated by exposure from overcorrected blepharoptosis.
Results: A 70-year-old woman with a history of amyloidosis was referred with bilateral eyelid retraction 1 month after levator aponeurosis advancement surgery. Examination demonstrated visual acuities of count-fingers OD and 20/400 OS and severe corneal epithelial irregularity with diffuse fluorescein staining. She had marked eyelid retraction with 5-mm right and 3-mm left superior scleral show and incomplete closure. Corneas were anesthetic, and neurologic examination was notable for peripheral sensory loss. Despite eyelid position normalization, the corneal abnormalities progressed to large epithelial defects refractory to aggressive lubrication, punctal occlusion, bandage contact lenses, extended patching, and ultimately tarsorrhaphy consistent with neurotrophic keratopathy. One year postoperatively, the epithelial disease persists.
Conclusion: Neurotrophic keratopathy can occur in association with amyloidosis and may be precipitated by exposure related to blepharoptosis repair.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/ICO.0b013e318191bdae | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Incidence of corneal perforation and lagophthalmos in patients with leprosy in Japan based on 40-year observations.
Jpn J Ophthalmol
January 2025
Miyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, 885-0051, Miyazaki, Japan.
Purpose: This study aimed to report the incidence, characteristics, and prognosis of corneal perforation in patients with leprosy.
Study Design: Retrospective observational study.
Methods: Patients who presented with leprosy and visited a specialised ophthalmology hospital (Miyata Eye Hospital, Miyazaki, Japan) between 1980 and 2020 were included.
Substance P- and Insulin-like Growth Factor 1-derived Tetrapeptides for Neurotrophic Keratopathy Related to Leprosy: A Clinical Trial.
Ophthalmol Sci
October 2024
Medical Information Center, Kyushu University Hospital, Fukuoka, Japan.
Purpose: Neurotrophic keratopathy is part of the leprosy sequelae and causes progressive deterioration of visual acuity. Although leprosy is bacteriologically curable, there is currently no efficient treatment. Eye drops containing tetrapeptides, phenylalanine-glycine-leucine-methionine-amide (FGLM-NH) and serine-serine-serine-arginine (SSSR), derived from substance P and insulin-like growth factor 1, are clinically efficacious in the treatment of corneal epithelial disorders caused by neurotrophic keratopathy.
View Article and Find Full Text PDFAutologous blood in the management of ocular surface disorders.
World J Exp Med
December 2024
Department of Optometry, University of Benin, Benin 3000283, Nigeria.
Autologous blood therapy has emerged as a promising modality in managing ocular surface disorders. This review provides a comprehensive overview of the current literature regarding the use of autologous blood in ocular surface disorders, encompassing its physiological basis, clinical applications, techniques, challenges, and future perspectives. The ocular surface, comprising the cornea, conjunctiva, and tear film, plays a critical role in maintaining visual function, and its disruption can lead to various pathological conditions.
View Article and Find Full Text PDFThe role of lysophosphatidic acid and its receptors in corneal nerve regeneration.
Ocul Surf
December 2024
Laboratory of Experimental Ophthalmology, Department of Ophthalmology, Pius-Hospital, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Germany. Electronic address:
The integrity of corneal nerves is critical for ocular surface health, and damages can lead to Neurotrophic Keratopathy (NK). Despite the regenerative abilities of the peripheral nerve system (PNS), corneal nerve regeneration is often incomplete, and the underlying mechanisms are poorly understood. This study aims to identify potential factors that can enhance corneal nerve regeneration for NK treatment, with a focus on Lysophosphatidic acid (LPA).
View Article and Find Full Text PDFTopical insulin used alone or in combination with drug-depository contact lens for refractory cases of neurotrophic keratopathy.
Am J Ophthalmol Case Rep
December 2024
Eye Clinic, Department of Surgical Sciences, University of Cagliari, Cagliari, 09124, Italy.
Purpose: To report the clinical outcomes achieved in refractory cases of neurotrophic keratopathy (NK) through the utilization of insulin eye drops alone or in conjunction with a drug-depository contact lens (DDCL).
Observations: This multicentric prospective open-label uncontrolled case series included consecutive patients with NK refractory to conventional treatment. Insulin eye drops (1 unit/mL) were prescribed 4 times/day in all cases, and a Therapeutic Hyper-CL™ soft contact lens (EyeYon Medical, Ness Ziona, Israel), designed to act as a drug reservoir, was applied in selected patients.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!