In modern medicine the term "functional symptoms" is usually used to refer to symptoms where an organic cause cannot be found. Studies have shown that up to half of all patients consulting their family physician and approximately one third of all those attending neurology outpatient clinics present with such symptoms. These patients commonly go between doctors, repeatedly undergo unnecessary tests, even surgery, and various drugs are tried with limited success. These problems tend to be prolonged and greatly reduce the quality of life for the patients involved. Both the DSM IV and ICD 10 classifications include a group for the so-called medically unexplained disorders. Among these disorders is conversion disorder where patients present with neurological symptoms, affecting motor or sensory function, but with no neurological explanation. Here we provide an overview of the current ideas on the aetiology, diagnosis, treatment and prognosis of conversion disorder.
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Mol Cell Neurosci
December 2024
Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Izmir, Türkiye; Izmir International Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Türkiye; Department of Neuroscience, Institute of Health Sciences, Dokuz Eylul University, Izmir, Türkiye. Electronic address:
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by the accumulation of amyloid plaques, phosphorylated tau tangles and microglia toxicity, resulting in neuronal death and cognitive decline. Since microglia are recognized as one of the key players in the disease, it is crucial to understand how microglia operate in disease conditions and incorporate them into models. The studies on human microglia functions are thought to reflect the post-symptomatic stage of the disease.
View Article and Find Full Text PDFBrain Commun
December 2024
Faculty of Science and Medicine, University of Fribourg, Fribourg 1700, Switzerland.
Individuals diagnosed with functional neurological disorder experience abnormal movement, gait, sensory processing or functional seizures, for which research into the pathophysiology identified psychosocial contributing factors as well as promising biomarkers. Recent pilot studies suggested that (epi-)genetic variants may act as vulnerability factors, for example, on the oxytocin pathway. This study set out to explore endogenous oxytocin hormone levels in saliva in a cohort of 59 functional neurological disorder patients and 65 healthy controls comparable in sex and age.
View Article and Find Full Text PDFJ Affect Disord
December 2024
Chongqing Key Laboratory of Cerebrovascular Disease Research, Chongqing, 400016, China; Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, 400016, China; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address:
Major depressive disorder (MDD) is a destructive mental disease, yet the mechanism is still not clear. Carbonic anhydrase, an efficient catalyst for CO conversion to carbonate and protons, could affect many functions, such as memory formation recognition. Lately, we illustrated that carbonic anhydrase 1 (CAR1) knockout (CAR1) mice could lead to depressive-like behaviors, but the underlying molecular mechanism is unknown.
View Article and Find Full Text PDFJ Proteomics
December 2024
TAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France; Endocrinology Department, University Hospital of Saint-Etienne, Saint-Etienne, France; Eating Disorder Reference Center, University hospital of Saint-Etienne, Saint-Etienne, France.
Understanding biological mechanisms underlying anorexia nervosa (AN) is necessary to develop care strategies. Despite many articles dedicated to peptides assessment in AN, there is no systematic review. A scoping review of circulating peptides published in relation to AN, comparing their results with those of controls, was conducted.
View Article and Find Full Text PDFStem Cell Res Ther
December 2024
Reproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, No. 20 Zhengdong Road, Zhenjiang, Jiangsu Province, 212001, China.
Background: Premature ovarian insufficiency (POI) is an ovarian dysfunction disorder that significantly impacts female fertility. Ovarian granulosa cells (GCs) are crucial somatic components supporting oocyte development that rely on glycolysis for energy production, which is essential for follicular growth. Hypoxia-induced exosomal circRNAs regulate glycolysis, but their biological functions and molecular mechanisms in POI are largely unexplored.
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