AI Article Synopsis
- Elevated plasma homocysteine (Hcy) levels are linked to various cardiovascular diseases and conditions like venous thrombosis.
- A portion of Hcy converts to homocysteine thiolactone (HcyT) more frequently in people with high Hcy levels, which then transforms back to Hcy through the action of the paraoxonase (PON) enzyme.
- A study found no significant difference in serum PON activity when examining the effects of a mild hyperhomocysteinemic diet, indicating that the enzyme's protective role may not work effectively in this context (p=0.19).
Article Abstract
Elevated plasma homocystein (Hcy) level has been recognized as an important risk factor for a number of cardiovascular diseases, peripheral arterial occlusive disease and venous thrombosis. A part of Hcy in the organism is turned to homocysteine thiolactone (HcyT) via a ring closure reaction, which gains rate in hyperhomocysteinemia, and in turn undergoes a hydrolytic reaction back to Hcy by paraoxonase enzyme (PON). Since this is a protective reflex action enzyme against hyperhomocysteinemia, we investigated how a mild hyperhomocysteinemic nutritional habit affected serum PON activity in a population-based study. The difference detected via enzymatic activity using the paraoxon substrate was statistically non-significant (p=0.19), suggesting a defective performance to reflect the expected significance. Determination of serum PON activity via substrate paraoxon yielded no significant difference in an acute mild hyperhomocysteinemic diet model in humans.
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| http://dx.doi.org/10.1016/j.ijcard.2009.03.138 | DOI Listing |
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