AI Article Synopsis
- Aedes albopictus mosquitoes in Potosi, Mo., were tested for their ability to transmit a new Bunyamwera sero group virus after being fed artificial blood infected with varying virus concentrations.
- After incubation at 25 degrees C for 7 to 29 days, a significant majority of the mosquitoes developed infections, with transmission first noted after 7 days; however, the overall transmission to other hosts was limited.
- Additionally, while some hamsters showed viremia after receiving a virus injection, a high mortality rate was observed in suckling mice given direct injections, indicating the virus's potential lethality in certain animal models.
Article Abstract
Aedes albopictus (Skuse) mosquitoes collected in Potosi, Mo., were tested for their ability to transmit a newly recognized Bunyamwera sero group virus isolated from the same mosquito population. Mosquitoes were fed artificial blood meals containing 4.5-6.2 log10 TCID50 of virus per ml. After 7-29 d at 25 degrees C, 79-99% of the mosquitoes had disseminated infections and 0-26% transmitted virus to fluid-filled capillary tubes. Transmission was first observed after 7 d of extrinsic incubation. Tests failed to detect transovarial transmission in 5,145 progeny from ovarian cycles 2-4. Following parenteral inoculation with 5.3-6.0 log10 TCID50 of virus, four of nine adult hamsters developed viremia. Ten of 16 suckling mice died following intracerebral inoculation of 5.0 log10 TCID50 of virus (fifth Vero cell passage); the average survival time was 8.8 d (SD, 3.5). No mortality occurred in 10 suckling mice inoculated with 3.6 log10 TCID50 of virus (second Vero cell passage).
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