AI Article Synopsis
- The study compares the SmartPill, a wireless capsule, with traditional radiopaque markers (ROMs) for assessing colonic transit time (CTT) and other gut transit metrics in constipated and healthy individuals.
- It finds that constipation is linked to slower gastric emptying and transit times, with notable differences observed between genders.
- The SmartPill shows good correlation with ROMs and boasts a high specificity for diagnosing constipation, suggesting it could be a more standardized, non-radiative option for gut transit assessment.
Article Abstract
Background & Aims: Colonic transit time (CTT) traditionally is assessed with radiopaque markers (ROMs), which requires radiation and is hindered by lack of standardization and compliance. We assessed regional and CTT with the SmartPill (SmartPill Corporation, Buffalo, NY), a new wireless pH and pressure recording capsule, in constipated and healthy subjects and compared this with ROM.
Methods: Seventy-eight constipated (Rome II) and 87 healthy subjects ingested a 260-kcal meal, a ROM capsule, and the SmartPill. Subjects wore a data receiver and kept daily stool diaries for 5 days. SmartPill recordings assessed CTT, whole-gut transit time (WGTT), small-bowel transit time, and gastric emptying time. Abdominal radiographs on days 2 and 5 assessed ROM transit. Sensitivity/specificity and receiver operating characteristics (ROCs) of each technique and utility were compared.
Results: Gastric emptying time, CTT, and WGTT were slower (P < .01) in constipated subjects than controls. CTT was slower in women than men (P = .02). Day 2 and day 5 ROM transits were slower (P < .001) in constipated subjects. Correlation of the SmartPill CTT with ROMs expelled on day 2/day 5 was r = 0.74/r = 0.69 in constipation, and r = 0.70/r = 0.40 in controls, respectively. The diagnostic accuracy of the SmartPill CTT to predict constipation from ROC was 0.73, with a specificity of 0.95. These were comparable with those of day 5 ROM (ROC, 0.71; specificity, 0.95).
Conclusions: The SmartPill is a novel ambulatory technique of assessing regional (gastric, small bowel, colonic) and WGTT without radiation. It reveals hitherto unrecognized gender differences and upper-gut dysfunction in constipation. It correlates well with ROM and offers a standardized method of discriminating normal from slow colonic transit.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cgh.2009.01.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cancer-Associated Fibroblast-Secreted Exosomes Regulate Macrophage Polarization in Pancreatic Cancer via the NOD1 Pathway.
J Biochem Mol Toxicol
January 2025
Department of Pathology and Pathophysiology, School of Medicine, Jinan University, Guangzhou, China.
Metastasis is a major cause of poor prognosis of pancreatic cancer. Exosomes (Exos) regulate cancer progression by modulating macrophage polarization. This study aimed to investigate the effects of cancer-associated fibroblast (CAF)-released Exos on macrophage polarization in pancreatic cancer and the molecular mechanisms.
View Article and Find Full Text PDFSoft grid integration control strategy for self synchronized voltage source DFIG wind turbine generator.
Sci Rep
January 2025
School of Electrical Engineering, Nanjing Vocational University of Industry Technology, Nanjing, 210023, China.
Transitioning to a power system heavily reliant on renewable wind energy involves more than just replacing conventional fossil-fuel-based power plant with wind farms, the wind energy must be able to meet the requirement of voltage establishment and power balance. It is believed that the self synchronized voltage source control of DFIG wind turbine generator is one of the possible solutions to realize virtual inertia and is helpful to increase the frequency stability of power system, thus is meaningful in the transformation of the power system dominated by renewable energy. Plenty of research has been conducted on the self synchronized voltage source control strategy in steady state, but few research is focused on the soft grid integration, which is a complicated process involving wind turbine control and power converter control.
View Article and Find Full Text PDFAn ultrafast algorithm for ultrafast time-resolved coherent Raman spectroscopy.
Commun Chem
January 2025
Energy & Materials Transition, Netherlands Organization for Applied Scientific Research (TNO), Urmonderbaan 22, Geleen, 6167RD, The Netherlands.
Time-resolved coherent Raman spectroscopy (CRS) is a powerful non-linear optical technique for quantitative, in-situ analysis of chemically reacting flows, offering unparalleled accuracy and exceptional spatiotemporal resolution. Its application to large polyatomic molecules, crucial for understanding reaction dynamics, has thus far been limited by the complexity of their rotational-vibrational Raman spectra. Progress in developing comprehensive spectral codes for these molecules, a longstanding goal, has been hindered by prohibitively long computation times required for their spectral synthesis.
View Article and Find Full Text PDFWellbeing and the Lived Experience of Injured Workers Following Finalisation of a Workers' Compensation Claim.
J Occup Rehabil
January 2025
Faculty of Health Sciences, Curtin School of Allied Health, Curtin University, Perth, WA, Australia.
Purpose: Workers' compensation claims can negatively affect the wellbeing of injured workers. For some, these negative effects continue beyond finalisation of the workers' compensation claim. It is unclear what factors influence wellbeing following finalisation of a workers' compensation claim.
View Article and Find Full Text PDFEffects of intermittent theta burst stimulation on cognitive and swallowing function in patients with MCI and dysphagia risk: a randomized controlled trial.
BMC Geriatr
January 2025
Department of Rehabilitation Medicine (Rehabilitation Center), Qilu Hospital of Shandong University, No. 107, Wenhuaxi Road, Jinan , Shandong, 250012, China.
Background: Mild cognitive impairment (MCI) is a high-risk factor for dementia and dysphagia; therefore, early intervention is vital. The effectiveness of intermittent theta burst stimulation (iTBS) targeting the right dorsal lateral prefrontal cortex (rDLPFC) remains unclear.
Methods: Thirty-six participants with MCI were randomly allocated to receive real (n = 18) or sham (n = 18) iTBS.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!