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Primary and Metastatic Pancreatic Ewing Sarcomas: A Case Report and Review of the Literature.
Diagnostics (Basel)
November 2024
Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece.
Ewing sarcomas are rare tumors arising mainly in the bones and the surrounding soft tissues. Primary extraosseous Ewing sarcomas have also been described in several other organs and locations other than bones, including the pancreas. These tumors have well-defined histological, immunohistochemical, and molecular characteristics.
View Article and Find Full Text PDFPDX1 as a Marker of Early Differentiation of Human Pancreatic Duct Cells.
Bull Exp Biol Med
November 2024
Avtsyn Research Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow, Russia.
Epithelial progenitor cells of the primitive pancreatic ducts differentiate in 3 directions, which is accompanied by changes in cell phenotype. We analyze the distribution of the pancreatic and duodenal homeobox 1 (PDX1) in the epithelial cells of pancreatic ducts during the prenatal development in order to determine the potential use of this marker as an indicator of pancreatic cell maturation. Pancreatic autopsies from human fetuses (gestation weeks 17-23) were examined by immunohistochemical methods.
View Article and Find Full Text PDFIntestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids.
Nat Commun
November 2024
Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Hubei Hongshan Laboratory, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Wuhan, 430072, China.
Although the metabolism of yolk lipids such as docosahexaenoic acid (DHA) is pivotal for embryonic development, the underlying mechanism remains elusive. Here we find that the zebrafish hydroxysteroid (17-β) dehydrogenase 12a (hsd17b12a), which encodes an intestinal epithelial-specific enzyme, is essential for the biosynthesis of long-chain polyunsaturated fatty acids in primitive intestine of larval fish. The deficiency of hsd17b12a leads to severe developmental defects in the primitive intestine and exocrine pancreas.
View Article and Find Full Text PDFA differentiation protocol for generating pancreatic delta cells from human pluripotent stem cells.
Front Cell Dev Biol
October 2024
Department of Testing and Diagnosis Technology Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.
In this protocol, we detail a seven-stage differentiation methodology for generating pancreatic delta cells (SC-delta cells) from human pluripotent stem cells (hPSCs). In the first step, definitive endoderm is generated by activin A and CHIR99021, followed by induction of primitive gut tube and posterior foregut by treatment with FGF7, SANT1, LDN193189, PdBU, and retinoic acid (RA). The subsequent endocrine generation and directed SC-delta cell induction is achieved by a combined treatment of the FGF7 with FGF2 during stage 4 and 5, together with RA, XXI, ALK5 inhibitor II, SANT1, Betacellulin and LDN193189.
View Article and Find Full Text PDFFine Needle Aspiration Cytology of Pancreatoblastoma in Adult/Adolescent Patients, One With Histology Mimicking NUT Carcinoma.
Diagn Cytopathol
October 2024
Department of Pathology and Laboratory Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
Article Synopsis
- Pancreatoblastoma is a rare malignant tumor primarily affecting children, but can occasionally appear in adults, complicating cytologic diagnosis because of its mixed cellular structure and the need for squamoid nests.
- Two patients were studied: one was a 38-year-old male with pancreatic and liver lesions featuring a biphasic malignancy, while the second was a 24-year-old female with a past diagnosis related to Gardner's syndrome, showing atypical cells in lymph nodes.
- The study also included a literature review discussing differential diagnosis and necessary tests for accurate identification of pancreatoblastoma.
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