Objectives/hypothesis: To introduce the concept of selective endoscopic decompression of the orbital apex for dysthyroid optic neuropathy and present surgical outcomes.
Study Design: Prospective case series.
Methods: Consecutive patients undergoing urgent endoscopic orbital apex decompression for dysthyroid optic neuropathy were studied prospectively. Surgical indications consisted of retrobulbar optic neuropathy with radiologic evidence of apical crowding in the setting of Graves' disease. Pre- and postoperative parameters assessed included exophthalmometry, visual acuity, presence or absence of exposure keratitis, diplopia, an afferent papillary defect, and Ishihara color plate testing.
Results: In all patients, visual acuity was improved or was stabilized by selective orbital apex decompression. Preoperative afferent papillary defects were reversed in all but one patient. Patients with decreased color vision by Ishihara color plate testing had postoperative improvement in their scores. No patients developed postoperative diplopia. An average of 3.1 mm of ocular recession was achieved.
Conclusions: Selective decompression of the orbital apex spares the anteromedial and inferior orbital walls that are typically removed in a standard endoscopic orbital decompression. This focused approach successfully addresses compressive optic neuropathy, while minimizing the risk of postoperative diplopia or delayed sinus outflow obstruction. In patients with progressing dysthyroid optic neuropathy without diplopia this modified procedure should be considered. Laryngoscope, 2009.
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http://dx.doi.org/10.1002/lary.20240 | DOI Listing |
Medicina (Kaunas)
December 2024
Clinic for Eye Disease, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
. Leber hereditary optic neuropathy (LHON) is a condition characterized by bilateral acute or subacute vision loss in seemingly healthy individuals. Depending on the disease stage and initial presentation, it is often diagnosed as optic neuritis.
View Article and Find Full Text PDFGenes (Basel)
January 2025
Eye Hospital, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
The study presents a detailed examination and follow-up of a Slovenian patient with an Leber Hereditary Optic Neuropathy (LHON)-like phenotype and bilateral optic neuropathy in whom genetic analysis identified a novel variant :m.15309T>C (Ile188Thr). We provide detailed analysis of the clinical examinations of a male patient with bilateral optic neuropathy from the acute stage to 8 years of follow-up.
View Article and Find Full Text PDFGenes (Basel)
January 2025
Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Background/objectives: A heterozygous mutation in the gene is responsible for autosomal dominant non-syndromic hearing loss (DFNA6/14/38) and Wolfram-like syndrome, which is characterized by bilateral sensorineural hearing loss with optic atrophy and/or diabetes mellitus. However, detailed clinical features for the patients with the heterozygous p.A684V variant remain unknown.
View Article and Find Full Text PDFBMC Ophthalmol
January 2025
Institute for Vision Research, University of Iowa, Iowa City, IA, United States.
Background: Endothelin is a potent vasoconstrictor and contributes to the regulation of vascular perfusion. Aberrant endothelin-1 (ET-1) levels in aqueous humor have been reported across a variety of vascular diseases of the eye, including glaucoma. These findings suggest that dysregulation of ET-1 production may contribute to glaucoma pathophysiology.
View Article and Find Full Text PDFSurv Ophthalmol
January 2025
University of Pittsburgh, School of Medicine, PA, USA. Electronic address:
The global increase in the prevalence of type 2 diabetes has led to the development and implementation of new classes of anti-diabetic medications, introducing advanced therapeutic options for the management of the disease. These new medications, though primarily designed to regulate blood glucose levels, also have applications in weight management, potentially transforming the current approaches to diabetes treatment. Newer medications, however, have ophthalmic side effects with controversies in trials and real-life data.
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