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SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes.
J Genet
April 2009
Laboratorio di Citogenetica, Oasi Institute for Research on Mental Retardation and Brain Aging, Troina 94018, Italy.
The incidence of melanoma has dramatically increased in many countries (it is 4.5 cases every 100 000 inhabitants in Sicily) and Xq27 region contains genes important in cancer like the SPANX (sperm protein associated with the nucleus in the X chromosome) gene family. These genes, made up of two exons separated by an intron of about 650 base pair, are expressed in sperm cells and in many tumours, including melanoma.
View Article and Find Full Text PDFMutational analysis of SPANX genes in families with X-linked prostate cancer.
Prostate
June 2007
Laboratory of Molecular Pharmacology, National Cancer Institute, NIH, Bethesda, Maryland, USA.
Background: Previous genetic linkage studies identified a locus for susceptibility to prostate cancer called HPCX at Xq27. The candidate region contains two clusters of SPANX genes. The first cluster called SPANX-A/D includes SPANX-A1, SPANX-A2, SPANX-B, SPANX-C, and SPANX-D; the second cluster called SPANX-N includes SPANX-N1, SPANX-N2, SPANX-N3, and SPANX-N4.
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