AI Article Synopsis
- Persistent DNA double-strand breaks and telomeres pose significant genomic risks due to their potential to trigger incorrect repair processes.
- Two recent studies demonstrate that Mps3, a SUN domain protein, sequesters these hazardous DNA ends, protecting them from the rest of the genome.
- This research highlights the nuclear periphery as a specialized area where these dangerous DNA components are managed to maintain genomic stability.
Article Abstract
Persistent DNA double-strand breaks and telomeres represent genomic hazards, as they can instigate inappropriate repair reactions. Two recent papers by Oza and colleagues (pp. 912-917) and Schober and colleagues (pp. 928-938) show that both types of DNA ends are sequestered from bulk DNA by Mps3, a SUN domain protein that spans the inner nuclear membrane. Anchorage maintains telomere integrity and steers double-strand breaks toward specialized repair pathways. This work defines the nuclear periphery as a subcompartment where dangerous DNA elements can be handled with care.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763515 | PMC |
| http://dx.doi.org/10.1101/gad.1805309 | DOI Listing |
Publication Analysis
Top Keywords
persistent dna
8
nuclear periphery
8
double-strand breaks
8
dna
5
life edge
4
edge telomeres
4
telomeres persistent
4
dna breaks
4
breaks converge
4
converge nuclear
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!