Objective: This study aimed to clarify whether painful annular fissures stimulated during provocation diskography are the likely source of diskogenic pain.
Design: A retrospective analysis was conducted of prospectively collected data.
Setting: Multidisciplinary, academic spine center.
Patients: The study was completed in a cohort of 28 consecutive patients were enrolled presenting with 6 months duration of axial low-back pain recalcitrant to physical therapy, oral analgesics, and epidural steroid injections and who have diskogenic pain based on history, exam, magnetic resonance imaging, and diskography.
Interventions: Subjects underwent provocation diskography and analgesic diskography utilizing a balloon-tipped intradiskal catheter allowing intradiskal injection of anesthetic.
Outcome Measures: Visual analog scale, finger-to-floor distance were utilized as outcome measures.
Results: 80% of painful intervertebral disks as detected by provocation diskography were sufficiently anesthetized resulting in >50% reduction in low-back pain during analgesic diskography.
Conclusion: Diskogenic pain is in varying degrees caused by the sensitized nociocepters within annular tears.
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http://dx.doi.org/10.1111/j.1526-4637.2009.00602.x | DOI Listing |
PM R
January 2016
Physiatry Department, Hospital for Special Surgery, New York, NY; and Department of Rehabilitation Medicine, Weill Cornell Medical College, New York, NY(††). Electronic address:
Objective: To determine whether single injections of autologous platelet-rich plasma (PRP) into symptomatic degenerative intervertebral disks will improve participant-reported pain and function.
Design: Prospective, double-blind, randomized controlled study.
Setting: Outpatient physiatric spine practice.
J Pain Res
December 2014
Department of Orthopedic Surgery, CAPHRI Research School, Maastricht University Medical Center, Maastricht, the Netherlands.
There is still no clear definition of diskogenic low-back pain and no consensus on a generally agreed test, such as provocative diskography (PD), to diagnose painful disk degeneration, and probably more importantly, to predict the outcome of therapy intended to reduce pain that is presumed to be diskogenic in nature. Nevertheless, PD is the most specific procedure to diagnose diskogenic low-back pain. Its accuracy, however, is rather low or at best unknown.
View Article and Find Full Text PDFNeurol Clin Pract
August 2014
Departments of Radiology (TPM) and Neurology (JDB), Mayo Clinic, Rochester, MN.
Diskography (provocation diskography, disk stimulation) is an invasive diagnostic test performed to confirm or exclude internal disk disruption as the cause of axial spine pain. Diskography involves injecting fluid into the nucleus of the disk under manometric control; a positive response is reproduction of typical pain. Extensive but indirect literature validates diskography in the lumbar spine; it is less well-supported in the cervical or thoracic spine.
View Article and Find Full Text PDFPM R
November 2014
APM Spine and Sports Physicians, Virginia Beach, VA(‡).
Background: Low back pain is a leading cause of pain and disability. The intervertebral disk has been identified as the most common source of chronic low back pain. Although prior treatments directed at intervertebral disks have been disappointing, recent studies show promising improvement of pain and function after a single intradiskal injection of methylene blue.
View Article and Find Full Text PDFGlobal Spine J
June 2013
Department of Radiology, Center for Magnetic Resonance and Optical Imaging, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States.
T-1-rho (T1ρ) magnetic resonance imaging (MRI) and disc height ratio (DHR) are potential biomarkers of degenerative disk disease (DDD) related to biochemical composition and morphology of the intervertebral disk (IVD), respectively. To objectively detect DDD at an early stage, the hypothesis was tested that the average T1ρ relaxation time of the nucleus pulposus (NP) correlates with the disk height of degenerate IVDs, measured by MRI. Studies were performed on a 3-T Siemens Tim Trio clinical MRI scanner (Siemens Healthcare, Malvern, Pennsylvania, United States) on patients being treated for low back pain whose disks were categorized into (1) painful and (2) nonpainful subgroups based on provocative diskography and (3) age-matched healthy controls.
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