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A Skin Biopsy of the Abdominal Wall Without a Rash Is Safe and Effective in the Diagnosis of Systemic Amyloidosis.
Am J Dermatopathol
April 2025
Medical Doctor, Department of Plastic and Aesthetic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
The diagnosis of systemic amyloidosis is decided through histologic materials from biopsy from different organs. This is a retrospective study from the institutional database of our hospital and consisted of patients to being judged to need skin biopsy for the purpose of diagnosing systemic amyloidosis visiting dermatology between April 2005 and August 2022. A total of 30 patients underwent the skin biopsy of dermis and fatty tissue on abdominal wall without rash and a total of 36 specimens were obtained.
View Article and Find Full Text PDFSignificant Periocular Swelling as a Sign of Systemic Amyloidosis.
Ophthalmic Plast Reconstr Surg
March 2025
Department of Ophthalmology, University of California, San Francisco, San Francisco, California, U.S.A.
We report a case of a 66-year-old woman with 8 years of progressive bilateral periorbital fullness, eyelid edema, and skin laxity. She had a history of thyroid cancer, smoldering myeloma, and systemic amyloidosis. The exam demonstrated significant bilateral periorbital fullness with mild limitation of extraocular motility in all directions bilaterally without double vision.
View Article and Find Full Text PDFPhenotype variability and therapeutic response to Patisiran in patients with hereditary transthyretin amyloidosis: a Belgian real-world experience.
Acta Clin Belg
February 2025
Department of Cardiology, Hôpital universitaire de Bruxelles, CUB Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
Introduction: Hereditary transthyretin amyloidosis (hATTRv) is a rare, genetic, adult-onset, multisystemic disorder which can affect diverse organs, including peripheral nerves, heart, kidneys, gastrointestinal tract, liver, skin and eyes. Currently, several disease-modifying treatments for hATTRv are available in Belgium including the TTR stabilizer tafamidis and TTR mRNA silencers patisiran and vutrisiran. Patisiran contains a small interfering RNA encapsulated into a lipid nanoparticle to deliver to hepatocytes, the main source of TTR protein production, thereby reducing TTR production.
View Article and Find Full Text PDFA systematic review and meta-analysis of treatments and outcomes of primary localized cutaneous amyloidosis.
Clin Exp Dermatol
February 2025
Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: Primary localized cutaneous amyloidosis (PLCA) is a skin-limited disorder characterized histologically by amyloid deposition in the papillary dermis. This study aimed to review current treatment strategies and provide an updated perspective on the treatment of PLCA.
Methods: We searched the PubMed, EMBASE and Cochrane Library databases for eligible studies.
The Efficacy of Off-Label Dupilumab in Cutaneous Amyloidosis.
J Cutan Med Surg
February 2025
Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, BC, Canada.
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