AI Article Synopsis
- Ischemia reperfusion injury (IRI) poses a significant challenge in organ transplantation, particularly affecting liver health.
- Research indicates that relaxin may help protect the liver from IRI by improving oxygen supply and reducing oxidative stress markers.
- In experiments with isolated rat livers, relaxin treatment showed enhanced oxygen distribution and lower levels of oxidative stress indicators, suggesting it could mitigate cell damage from IRI.
Article Abstract
Ischemia reperfusion injury (IRI) is a problem in organ transplantation. Relaxin is known to have a protective effect against liver injury caused by IRI. Using a model of isolated perfused rat liver, the local oxygen supply in liver tissue was investigated by spectrophotometric in vivo imaging and compared to the protective effect of relaxin shown by immunohistochemical measurement of myeloperoxidase and malonyldialdehyde activities as determinants of oxidative stress. In relaxin-treated liver tissue, spectrophotometry showed a better oxygen supply and decreased myeloperoxidase and malonyldialdehyde activities. Our data suggest that relaxin can influence the oxygen distribution in liver tissue and reduce cell damage caused by IRI.
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| http://dx.doi.org/10.1111/j.1749-6632.2008.03804.x | DOI Listing |
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