Estrogen regulates LGR7 (RXFP1) mRNA expression in an in vitro model of human term pregnancy cervix that utilizes lower uterine segment fibroblasts. LGR7 mRNA levels were increased by estradiol to mean levels of 152%+/- 5.9% above those in untreated control cells. Therefore, estradiol may amplify relaxin's actions in the cervix.
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Renal Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil.
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a Department of Obstetrics , Gynaecology and Reproductive Sciences, Outpatient Fertility Clinic, Second University of Naples, Largo Madonna Delle Grazie 1 , Naples 8 , Italy.
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Department of Animal Physiology and Neurobiology, Zoological Institute, KU Leuven, Naamsestraat 59, P.O. Box 2465, B-3000 Leuven, Belgium. Electronic address:
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