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A potent and selective activator of large-conductance Ca-activated K channels induces preservation of mitochondrial function after hypoxia and reoxygenation by handling of calcium and transmembrane potential.
Acta Physiol (Oxf)
June 2024
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
Aims: Ischaemic heart disease remains a significant cause of mortality globally. A pharmacological agent that protects cardiac mitochondria against oxygen deprivation injuries is welcome in therapy against acute myocardial infarction. Here, we evaluate the effect of large-conductance Ca-activated K channels (BKCa) activator, Compound Z, in isolated mitochondria under hypoxia and reoxygenation.
View Article and Find Full Text PDFDeveloping a post-myocardial infarction medicines optimisation clinic: core competencies for upskilling pharmacists and initial patient feedback.
BMJ Open Qual
April 2023
Cardio-Respiratory Department, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Background: Medicines optimisation and adherence support are essential to secondary prevention after myocardial infarction (MI). Following successful implementation of a consultant pharmacist-led post-MI medicines optimisation clinic, the service was expanded by training advanced clinical pharmacists to manage clinics (with appropriate multidisciplinary team support).
Methods: Key steps in the development process were: definition of a key competency framework based on relevant qualifications and experience, knowledge, skills and clinic management practicalities; creation and enaction of trainee-specific development plans to address gaps (including independent learning, teaching from multidisciplinary colleagues and shadowing in clinics); establishment of relevant protocols and proformas to ensure consistent standards (eg, a patient self-reporting tool for identifying adherence barriers, consultation proforma, directory of clinical parameters and pathway for onward referral when needed); phased clinic roll-out, initially under supervision; and gathering of feedback from patients and colleagues.
lifex-fiber: an open tool for myofibers generation in cardiac computational models.
BMC Bioinformatics
April 2023
MOX, Department of Mathematics, Politecnico di Milano, Milano, Italy.
Background: Modeling the whole cardiac function involves the solution of several complex multi-physics and multi-scale models that are highly computationally demanding, which call for simpler yet accurate, high-performance computational tools. Despite the efforts made by several research groups, no software for whole-heart fully-coupled cardiac simulations in the scientific community has reached full maturity yet.
Results: In this work we present [Formula: see text]-fiber, an innovative tool for the generation of myocardial fibers based on Laplace-Dirichlet Rule-Based Methods, which are the essential building blocks for modeling the electrophysiological, mechanical and electromechanical cardiac function, from single-chamber to whole-heart simulations.
Delayed Diagnosis and Recovery of Fulminant Immune Checkpoint Inhibitor-Associated Myocarditis on VA-ECMO Support.
JACC CardioOncol
December 2022
Cardiovascular Division, Washington University in St. Louis, St. Louis, Missouri, USA.
The effect of a Prasugrel- vs. a Ticagrelor-based strategy on total ischaemic and bleeding events in patients with acute coronary syndromes.
Eur Heart J Cardiovasc Pharmacother
April 2023
Deutsches Herzzentrum München, Department of Cardiology and Technische Universität München, 80636, Munich, Germany.
Aims: The effect of a prasugrel vs. a ticagrelor based strategy on total (including both first and recurrent) ischaemic and bleeding events in patients with acute coronary syndromes (ACS) has not been evaluated. The aim of this analysis was to investigate the treatment effect of a prasugrel vs.
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