A deficiency of the Escherichia coli Lon protease blocked paradoxical survival occurring at very high nalidixic acid concentrations. The absence of Lon also blocked a parallel increase in cell lysate viscosity likely to reflect DNA size. Thus, Lon may participate in repairing quinolone-mediated DNA lesions formed at high drug concentrations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704693 | PMC |
| http://dx.doi.org/10.1128/AAC.00019-09 | DOI Listing |
Publication Analysis
Top Keywords
lon protease
8
paradoxical survival
8
escherichia coli
8
lon
4
protease essential
4
essential paradoxical
4
survival escherichia
4
coli exposed
4
exposed high
4
high concentrations
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!