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Pervasive RNA-binding protein enrichment on TAD boundaries regulates TAD organization.
Nucleic Acids Res
January 2025
Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong SAR, China.
Mammalian genome is hierarchically organized by CTCF and cohesin through loop extrusion mechanism to facilitate the organization of topologically associating domains (TADs). Mounting evidence suggests additional factors/mechanisms exist to orchestrate TAD formation and maintenance. In this study, we investigate the potential role of RNA-binding proteins (RBPs) in TAD organization.
View Article and Find Full Text PDFConstruction of a 'civilised smoking environment': a novel strategy undermining tobacco control efforts in China.
Tob Control
January 2025
Key Lab of Public Health Safety of the Ministry of Education, School of Public Health, Fudan University, Shanghai, China
Objective: In 2018, the Chinese tobacco industry initiated the nationwide 'civilised smoking environment' campaign via a 5-year action plan. The goal of this study was to analyse content of reports regarding this topic as evidence to policy-makers to prevent interference from the tobacco industry.
Methods: A search of WiseNews, a Chinese media information service provider, for reports regarding the 'civilised smoking environment' between January 2018 and December 2022.
A Comprehensive Analysis In Silico of Genes in Maize Revealed Their Potential Role in Response to Abiotic Stress.
Plants (Basel)
December 2024
Scientific Observing and Experimental Station of Maize in Plain Area of Southern Region, Ministry of Agriculture and Rural Affairs, School of Life Sciences, Nantong University, Nantong 226019, China.
β-ketoacyl-CoA synthase (KCS) enzymes play a pivotal role in plants by catalyzing the first step of very long-chain fatty acid (VLCFA) biosynthesis. This process is crucial for plant development and stress responses. However, the understanding of genes in maize remains limited.
View Article and Find Full Text PDFOmics-driven onboarding of the carotenoid producing red yeast Xanthophyllomyces dendrorhous CBS 6938.
Appl Microbiol Biotechnol
December 2024
Life Sciences and Bioengineering Center, Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
Transcriptomics is a powerful approach for functional genomics and systems biology, yet it can also be used for genetic part discovery. Here, we derive constitutive and light-regulated promoters directly from transcriptomics data of the basidiomycete red yeast Xanthophyllomyces dendrorhous CBS 6938 (anamorph Phaffia rhodozyma) and use these promoters with other genetic elements to create a modular synthetic biology parts collection for this organism. X.
View Article and Find Full Text PDFBerberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models.
Inflammopharmacology
December 2024
Department of Zoology, Government College University, Faisalabad, 38000, Pakistan.
Berberine (BBR), an alkaloid derivative mostly found in Oregon grapes and barberry shoots, has several medical properties, including anti-microbial, anti-tumorigenic, and anti-inflammatory properties. As such, it is a superior alternative to presently recommended medications. From previous researches, which showed that BBR has anti-arthritic qualities by blocking a number of inflammatory signalling pathways.
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