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Stem cells derived exosomes and biomaterials to modulate autophagy and mend broken hearts.
Biochim Biophys Acta Mol Basis Dis
October 2023
Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Rady Faculty of Health Science, University of Manitoba, Winnipeg R2H2A6, MB, Canada. Electronic address:
Autophagy maintains cellular homeostasis and plays a crucial role in managing pathological conditions including ischemic myocardial injury leading to heart failure (HF). Despite treatments, no intervention can replace lost cardiomyocytes. Stem cell therapy offers potential for post-myocardial infarction repair but struggles with poor cell retention due to immune rejection.
View Article and Find Full Text PDFHow Can You Mend a Broken Heart?
Ann Fam Med
May 2023
University of Chicago Family Medicine, Chicago, Illinois
Being a resident is hard. Being a resident dealing with a recent breakup is even harder. I wrote this piece after a serendipitous encounter on Valentine's Day with an elderly woman who embraced her messy journey to finding love, no matter her age or circumstance.
View Article and Find Full Text PDFThe Role and Function of Autobiographical Memory Narratives during the Emotional Processing of Breast Cancer Treatment: An Empirically-Derived Memory Coding System.
Int J Environ Res Public Health
January 2023
Department of Psychology, Connecticut College, New London, CT 06107, USA.
Article Synopsis
- The study investigates how autobiographical memory narratives (AMN) help younger women with breast cancer adapt to medical treatment by analyzing their personal stories at different treatment stages.
- Researchers collected 68 AMNs from 17 women, focusing on aspects like agency, emotional regulation, and interpersonal relations, identifying a vulnerability in narrative identity during critical treatment shifts.
- The findings emphasize the importance of AMNs in understanding emotional adaptation and offer insights for clinicians on how women process their experiences with illness, contributing to their recovery and adaptation journey.
Brivaracetam Induced Encephalopathy: Why Mend Something Which isn't Broken.
Ann Indian Acad Neurol
March 2022
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Can you mend a broken heart? Awakening conventional metaphors in the maze.
Psychon Bull Rev
February 2022
Department of Psychology, Concordia University, 7141 Sherbrooke Street West, Montreal, QC, H4B 1R6, Canada.
Conventional metaphors such as broken heart are interpreted rather fast and efficiently. This is because they might be stored as lexicalized, noncompositional expressions. If so, they require sense retrieval rather than sense creation.
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