Purpose: To report a technique of intracameral injection of Tisseel fibrin sealant as an adjunct in the performance of tectonic deep anterior lamellar keratoplasty in cases with preexisting or intraoperative macroperforation.
Methods: Patients with corneal perforations up to 4 mm in greatest dimension first had the defect sealed externally with cyanoacrylate adhesive or fibrin sealant. An air bubble was injected into the anterior chamber (AC), followed by intracameral Tisseel fibrin sealant. This was injected via a 21-G cannula or needle, introduced into the AC from the limbus, with the tip positioned just under the perforation. Fibrin sealant was injected to completely cover the perforation site. Deep anterior lamellar keratoplasty then proceeded with a manual technique without chamber loss. Postoperatively, slit-lamp examination to assess resolution of fibrin sealant and graft status was performed, and visual acuities and intraocular pressures were recorded.
Results: Two patients with preexisting corneal perforations and 1 patient with an intraoperative perforation were included. In all patients, lamellar dissection proceeded uneventfully after intracameral fibrin injection. Fibrin sealant in the AC spontaneously resorbed by the second postoperative week. There were no postoperative intraocular pressure spikes and no cases of severe anterior uveitis. All grafts were clear at last follow-up with no evidence of endothelial decompensation.
Conclusions: Intracameral fibrin sealant injection seems to be a safe adjunct to allow completion of deep anterior lamellar keratoplasty in cases with corneal perforation with the aim of avoiding higher risk penetrating keratoplasty. Cases were characterized by a lack of complications postoperatively, and no cases of persistent double AC were encountered.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/ICO.0b013e31818ad9d0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Could Fibrin Sealants (TISSEEL) Be Effective in the Management of Burn Injuries? A Histopathological Study in Rats.
Med Sci (Basel)
December 2024
Laboratory of Experimental Surgery and Surgical Research "N.S. Christeas", School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Burn injuries remain a major clinical problem worldwide, which require special management by experienced plastic surgeons. However, they cannot be available in every healthcare unit; consequently, there is a need for effective treatment options that could be utilized by a wide range of non-expert healthcare professionals. The aim of the present experimental study was to investigate the safety and efficacy of using a fibrin sealant (TISSEEL) compared to the conventional treatment with sulfadiazine on partial-thickness burn in a rat animal model.
View Article and Find Full Text PDFEfficacy of Fibrin Sealant in Submental Liposuction: A Prospective Randomized Study.
Aesthetic Plast Surg
December 2024
Tokyo Chuo Beauty Clinic, K's Square Building 3F, 2-8-15 Sonezaki, Kita-ku, Osaka-shi, Osaka-fu, UmedaOsaka, Japan.
Background: The incidence rate of submental liposuction has been increasing in recent years. Although this procedure is relatively simple, serious complications, including fatalities, have been reported, primarily owing to intraoperative and postoperative bleeding.
Methods: To enhance the safety of liposuction, we examined the efficacy of Beriplast® P (CSL Behring, Melbourne, Australia), a physiological tissue adhesive fibrin sealant, in reducing postoperative swelling.
Background And Aims: An effective surgical adhesive must possess strength, biodegradability, flexibility, non-toxicity, and the ability to accommodate to tissue movement. However, existing adhesives in the market lack some of these crucial properties. Both synthetic cyanoacrylate and natural fibrin glue have been explored for sutureless oral surgery, but they come with specific limitations.
View Article and Find Full Text PDFLong-term Investigation of Annulargrams and Intra-annular Fibrin to Treat Chronic Discogenic Low Back Pain and Radiculopathy: 1-, 2-, and 3-Year Outcome Comparisons of Patients with and without Prior Surgery.
Pain Physician
November 2024
Longevity-New York, New York City, New York, USA; Institute for Mobility and Longevity, Ft. Myers, FL, USA; 411th Hospital Center, Armed Forces Reserve Center, Jacksonville, FL, USA; Adam Vital Hospital, Dubai, Unted Arab Emirates; Reem Hospital, Abu Dhabi, United Arab Emirates.
Article Synopsis
- Discogenic chronic low back pain (cLBP) and radiculopathy are common and disabling, with traditional treatments often leading to further complications or degeneration of spinal discs.
- A new treatment strategy focuses on diagnosing and treating annulus fibrosus tears by using fibrin to seal these injuries and promote tissue growth, potentially offering a safer and more effective alternative.
- This method was tested in a retrospective cohort study involving patients who had not found relief from multiple prior treatments for cLBP lasting over six months, utilizing MRI for diagnosis.
Fibrin-glue-assisted retinopexy for coloboma-associated retinal detachment.
Indian J Ophthalmol
December 2024
Srimati Kanuri Santhamma Center for Vitreo-Retinal Diseases, Anant Bajaj Retina Institute, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
Background: Retinal detachment (RD) is common (23%-40%) in eyes with uveal coloboma due to early vitreous syneresis, inherent defects at the locus minoris resistentiae, and breaks in intercalary membrane (ICM).[1] Managing eyes with coloboma RD is difficult due to complexity of accessing and repairing retinal breaks. In RD surgeries, tamponade agents are used to provide surface tension across retinal breaks to prevent further fluid flow into the subretinal space until the effect of retinopexy is permanent.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!