Increasing evidence suggests that multiple metabolic pathways are regulated by sirtuin-dependent protein deacetylation in the mitochondria. In this issue, Nakagawa et al. (2009) show that the sirtuin SIRT5 deacetylates and activates a mitochondrial enzyme, carbamoyl phosphate synthetase 1, which mediates the first step in the urea cycle.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310393 | PMC |
| http://dx.doi.org/10.1016/j.cell.2009.04.036 | DOI Listing |
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