The ocular counterroll (OCR) reflex generates partially compensatory torsional eye movements during static head roll tilt. We assessed the influence of age, viewing distance and target complexity on the OCR across the age span (13-63 years; n=47), by recording eye movements during head-on-body roll tilt (0+/-40 degrees in 5 degrees steps) while subjects viewed simple vs. complex targets at 0.33 and 1m. We found that subjects > or = 31 years had lower gains than those < or =30 years, but only for far targets. Consistent with prior reports, far targets elicited higher OCR gains than near targets, and target complexity had no effect on gains, suggesting that visual input is primarily used to maintain vergence during OCR.
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http://dx.doi.org/10.1016/j.visres.2009.04.021 | DOI Listing |
J Med Internet Res
January 2025
Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
Background: The rapid shift to video consultation services during the COVID-19 pandemic has raised concerns about exacerbating existing health inequities, particularly for disadvantaged populations. Intersectionality theory provides a valuable framework for understanding how multiple dimensions of disadvantage interact to shape health experiences and outcomes.
Objective: This study aims to explore how multiple dimensions of disadvantage-specifically older age, limited English proficiency, and low socioeconomic status-intersect to shape experiences with digital health services, focusing on video consultations.
J Med Chem
January 2025
Chemical Biology Section, Molecular Targets Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.
Autophagy, a recycling process in eukaryotes, contributes to tumor growth and metastasis by alleviating cellular stress and facilitating survival and chemoresistance. The development of small molecules that selectively inhibit this pathway has proven challenging and is required to determine if autophagy inhibition can be harnessed as an effective therapeutic strategy in cancer. Compound 19 was previously identified as a selective autophagy inhibitor that targets the ATG14L-Beclin1 protein-protein interaction, which regulates the formation, localization, and function of VPS34 Complex I to initiate autophagy.
View Article and Find Full Text PDFPLoS One
January 2025
College of Computer and Information Science, Southwest University, Chongqing, China.
The consumption forecasting of oil and coal can help governments optimize and adjust energy strategies to ensure energy security in China. However, such forecasting is extremely challenging because it is influenced by many complex and uncertain factors. To fill this gap, we propose a hybrid deep learning approach for consumption forecasting of oil and coal in China.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Hemolysin co-regulated protein 1 (Hcp1) is a component of the cluster 1 Type VI secretion system (T6SS1) that plays a key role during the intracellular lifecycle of Burkholderia pseudomallei. Hcp1 is recognized as a promising target antigen for developing melioidosis diagnostics and vaccines. While the gene encoding Hcp1 is retained across B.
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