Exp Mol Pathol
Department of Chemistry University of Louisville, Louisville, KY 40208, USA.
Published: August 2009
A subtype of non-small cell lung cancer, bronchioalveolar adenocarcinoma (BAC), is more prevalent in Asian female non-smokers, and is more likely to respond to treatment with tyrosine kinase inhibitors such as erlotinib and gefitinib. Nuclear magnetic resonance and mass spectrometry-based metabolomic analysis of extracts from two different lung lesions and surrounding non-cancerous tissues of a BAC patient showed novel protein and phospholipid-associated metabolic differences that correlated with tumor development as well as PET and erlotinib sensitivity.
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http://dx.doi.org/10.1016/j.yexmp.2009.04.004 | DOI Listing |
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