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Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat Accelerates Wound Healing in a Mouse Hind limb Lymphedema Model.
Adv Wound Care (New Rochelle)
January 2025
Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Drugs regulating hypoxia-inducible factor (HIF)-1α have not been investigated for wound healing in lymphedema. Therefore, we examined the effects of drug modulation of HIF-1α activity for wound healing in our previously developed mouse model of nonirradiated hind limb lymphedema. Mouse hind limb lymphedema models ( = 17) and a sham group ( = 6) were created using 8- to 10-week-old male C57BL/6N mice.
View Article and Find Full Text PDFHypoxia-inducible factor-targeting therapy augmented the sensitivity to programmed death ligand-1 blockade by enhancing interferon-γ-induced chemokines in tumor cells.
Int J Cancer
December 2024
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Immune checkpoint inhibitors (ICIs) targeting programmed death ligand-1 (PD-L1) provide clinical benefits for various advanced malignancies. However, the predictive factors that determine sensitivity to ICIs have not been fully elucidated. We focused on tumor-derived CXCL10/11 as a pivotal factor that determines the response to PD-L1 blockade by regulating T cell accumulation and tumor angiogenesis.
View Article and Find Full Text PDFPrecise evaluation of the nutritional value of yeast culture and its effect on pigs fed low-protein diets.
Anim Nutr
December 2024
College of Animal Science and Technology, Beijing College of Agriculture, Beijing 102206, China.
The purpose of the present study was to assess the nutritional value of yeast culture (YC) and to explore the effect of YC on growth performance and health of piglets fed low-protein diets. In Exp. 1, 12 growing barrows were allocated into control diet and YC diet treatments to determine the available energy of YC.
View Article and Find Full Text PDFHypoxia-inducible factor-1α promotes ferroptosis by inducing ferritinophagy and promoting lactate production in yak longissimus thoracis et lumborum postmortem.
Meat Sci
February 2025
College of Food Science and Engineering, Gansu Agricultural University, Lanzhou, Gansu 730070, China. Electronic address:
Ferroptosis has emerged as a novel, crucial regulator of meat quality in the postmortem hypoxia environment, with its role in mediating protein oxidation and cell death. However, the interaction between ferroptosis and the hypoxia response, especially the involvement of hypoxia-inducible factor-1α (HIF-1α), remains poorly studied. This study aimed to characterize whether HIF-1α influences ferroptosis, and, if so, explore the underlying mechanisms involved.
View Article and Find Full Text PDFArticle Synopsis
- HIF-1α plays a crucial role in helping tissues adapt to low oxygen conditions and this study looks at its effects on blood vessel formation in specific surgical flaps used in rats.
- The research involved 90 male Wistar rats divided into three groups, receiving different treatments after flap surgery to measure angiogenesis, using various testing methods including x-ray angiography and histological analysis.
- Results indicated that the group treated with DMOG showed significantly increased blood vessel density and higher levels of HIF-1α and VEGF compared to the other groups, suggesting that HIF-1α enhances blood vessel growth and may improve tissue survival in these surgical procedures.
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