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Radioligand therapy in sympathetic-adrenal-medullary axis tumors: state of art and perspectives.
Endocrine
October 2024
Nuclear Medicine Unit, Onco-Hematology Department, University Hospital of Ferrara, Ferarra, Italy.
Article Synopsis
- The approval of radioligand therapy (RLT) by EMA in 2017 and FDA in 2018 has led to its broader use in treating neuroendocrine neoplasms (NENs), particularly advanced well-differentiated gastro-entero-pancreatic types.
- However, RLT applications are limited to specific tumor types, leaving some tumors, like those from the sympathetic-adrenal-medullary (SAM) axis, as "RLT-orphans" that cannot currently benefit from this therapy.
- The paper explores theragnostic options for treating pheochromocytomas and paragangliomas, discussing traditional methods with MIBG and potential future applications using radiolabeled somat
A neuroendocrine biomarker revolution from monoanalyte to multianalyte biomarkers in non-functioning gastro-entero-pancreatic neuroendocrine neoplasms.
Crit Rev Oncol Hematol
November 2024
Division of Transplant Surgery, University of Colorado Anschutz Medical Campus, USA. Electronic address:
Neuroendocrine neoplasms (NENs) arise from neuroendocrine cells in a wide variety of organs. One of the most affected disease sites is the gastrointestinal system, which originates the gastro-entero-pancreatic NENs (GEP-NENs), a heterogenous group of malignancies that are rapidly increasing in incidence. These tumors can be functioning, with secretory activity leading to identifiable clinical syndromes, or non-functioning, with no secretory activity but with local symptoms of tumor growth and metastasis.
View Article and Find Full Text PDFGastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) - Current literature review of diagnostics and therapy. What has changed in the management?
Pol Przegl Chir
March 2024
Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Poland.
<b>Introduction:</b> Gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) are malignancies originating from cells of the diffuse endocrine system. They are rare and localize in the upper and lower parts of the gastrointestinal tract and in the pancreas. Despite such a varied location, GEP-NENs are considered a common group of neoplasms due to the fact of their similar morphology and ability to secrete peptide hormones and biologically active amines.
View Article and Find Full Text PDFAn Italian real-world multicenter study of patients with advanced mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) of the gastro-entero-pancreatic system treated with chemotherapy.
J Endocrinol Invest
September 2024
Division of Gastrointestinal Medical Oncology, Neuroendocrine Tumors, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
Purpose: The aim of this study is to describe the clinical management of an Italian series of patients with advanced gastro-entero-pancreatic (GEP) MiNENs treated in clinical practice.
Methods: Clinical records of patients from four Italian referral Centers were retrospectively analyzed to correlate clinical/biological data with clinical outcomes. All the surgical specimens were centrally reviewed.
Endoscopic Management of Gastro-Entero-Pancreatic Neuroendocrine Tumours: An Overview of Proposed Resection and Ablation Techniques.
Cancers (Basel)
January 2024
Royal Free Unit for Endoscopy, The Royal Free Hospital and University College London (UCL) Institute for Liver and Digestive Health, London NW3 2QG, UK.
A literature search of MEDLINE/PUBMED was conducted with the aim to highlight current endoscopic management of localised gastro-entero-pancreatic NETs. Relevant articles were identified through a manual search, and reference lists were reviewed for additional articles. The results of the research have been displayed in a narrative fashion to illustrate the actual state-of-the-art of endoscopic techniques in the treatment of NETs.
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