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Adipocyte-hepatocyte crosstalk in cellular models of obesity: Role of soluble factors.
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Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, Corso Europa 26, 16132, Genova, Italy. Electronic address:
Hepatic steatosis is often a consequence of obesity. Adipose tissue is an important endocrine regulator of metabolic homeostasis in the body. In obesity, adipocytes become hypertrophic and develop an inflammatory phenotype, altering the panel of secreted adipokines.
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Metabolic syndrome and robustness tradeoffs.
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Sony Computer Science Laboratories, Inc. 3-14-13, Higashi-Gotanda, Shinagawa, Tokyo 141-0022 Japan.
The metabolic syndrome is a highly complex breakdown of normal physiology characterized by obesity, insulin resistance, hyperlipidemia, and hypertension. Type 2 diabetes is a major manifestation of this syndrome, although increased risk for cardiovascular disease (CVD) often precedes the onset of frank clinical diabetes. Prevention and cure for this disease constellation is of major importance to world health.
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