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Antibody response to Plasmodium vivax in the context of Epstein-Barr virus (EBV) co-infection: A 14-year follow-up study in the Amazon rainforest.
PLoS One
January 2025
Instituto René Rachou, Fiocruz Minas, Fundação Oswaldo Cruz (Fiocruz), Belo Horizonte, Minas Gerais, Brazil.
Background: To develop an effective vaccine against Plasmodium vivax, the most widely dispersed human malaria parasite, it is critical to understand how coinfections with other pathogens could impact malaria-specific immune response. A recent conceptual study proposed that Epstein-Barr virus (EBV), a highly prevalent human herpesvirus that establishes lifelong persistent infection, may influence P. vivax antibody responses.
View Article and Find Full Text PDF2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione protects against MPP-induced neurotoxicity by ameliorating oxidative stress, apoptosis and autophagy in SH-SY5Y cells.
Metab Brain Dis
January 2025
Key Laboratory of Longevity and Aging-Related Disease of Chinese Ministry of Education, Center for Translational Medicine, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China.
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) is a cyclohexanedione compound extracted from the roots of Averrhoa carambola L. Several studies have documented its beneficial effects on diabetes, Alzheimer's disease, and cancer. However, its potential neuroprotective effects on Parkinson's disease (PD) have not yet been explored.
View Article and Find Full Text PDFA Game of Life with dormancy.
Proc Biol Sci
January 2025
Department of Biology, Indiana University, Bloomington, IN 47405, USA.
The factors contributing to the persistence and stability of life are fundamental for understanding complex living systems. Organisms are commonly challenged by harsh and fluctuating environments that are suboptimal for growth and reproduction, which can lead to extinction. Many species contend with unfavourable and noisy conditions by entering a reversible state of reduced metabolic activity, a phenomenon known as dormancy.
View Article and Find Full Text PDFAssociation of chronic low back pain and knee pain with subjective fatigue incidence among community-dwelling older adults: A prospective cohort study.
Geriatr Gerontol Int
January 2025
Department of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
Aim: Fatigue is a common health problem in older adults. Chronic pain is associated with fatigue. However, the longitudinal association between chronic pain and the incidence of subjective fatigue among community-dwelling older adults remains unclear.
View Article and Find Full Text PDFDevelopment and validation of a prediction model of frailty risk in community-dwelling older adults: From a national longitudinal survey.
Public Health
January 2025
The Second Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu 215004, PR China. Electronic address:
Objectives: This study aimed to develop and validate a risk prediction model for frailty in elderly using a nationally representative longitudinal survey database.
Study Design: Longitudinal study based on public databases.
Methods: Three continuous cohorts of elderly aged 65 years or older from the Chinese Longitudinal Healthy Longevity Survey, with the 2008-2018 cohort as the development cohort.
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