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Metamorphic Proteins to Achieve Conformationally Selective Material Surface Binding.
Small
January 2025
Department of Chemistry, University of Miami, Coral Gables, FL, 33146, USA.
The controlled binding of proteins on nanoparticle surfaces remains a grand challenge required for many applications ranging from biomedical to energy storage. The difficulty in achieving this ability arises from the different functional groups of the biomolecule that can adsorb on the nanoparticle surface. While most proteins can only adopt a single structure, metamorphic proteins can access at least two different conformations, which presents intriguing opportunities to exploit such structural variations for binding to nanoparticles.
View Article and Find Full Text PDFProgress on ancient DNA investigation of Late Quaternary mammals in China.
Yi Chuan
January 2025
State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430078, China.
It has been more than 40 years since the beginning of exploring the genetic composition of ancient organisms from the perspective of ancient DNA. In the recent 20 years, with the development and application of high-throughput sequencing technology platforms and the improved efficiency of retrieving highly fragmented DNA molecules, ancient DNA research moved forward to a brand-new era of deep-time paleogenomics. It not only solved many controversial phylogenetic problems, enriched the migration and evolution details of various organisms including humans, but also launched exploration of the molecular responses to climate changes in terms of "whole genomic-big data-multi-species" level.
View Article and Find Full Text PDFNosocomial Pneumonia in Georgia: A Study of Extended Spectrum Beta-Lactamase (ESBL)-Producing Versus Non-extended ESBL Gram-Negative Bacterial Profiles.
Cureus
December 2024
Biomedical Sciences, Georgian American University (GAU), Tbilisi, GEO.
Background: Nosocomial pneumonia is a significant healthcare challenge, particularly in the face of rising antimicrobial resistance among Gram-negative bacteria. The production of extended spectrum beta-lactamase (ESBL) exacerbates treatment complexities.
Aim: This study investigates the prevalence and resistance patterns of ESBL-producing and non-ESBL Gram-negative bacteria in nosocomial pneumonia cases in Georgian hospitals to inform antibiotic stewardship and treatment strategies.
The Challenges Associated with : Barriers to Implementing Naturalistic Developmental Behavioral Interventions in ABA Settings.
Behav Anal Pract
December 2024
Department of Pediatrics, Division of Autism and Related Disabilities, Emory School of Medicine, 1920 Briarcliff Road, Atlanta, GA 30329 USA.
Unlabelled: Naturalistic developmental behavioral intervention (NDBI) supports early social communication skills in young autistic children. Given their emphasis on child-led learning opportunities, NDBI is thought to be a socially valid approach to autism early intervention. Applied behavior analysis (ABA) practices could be an ideal setting to increase access to NDBIs for young autistic children; however, current ABA services continue to rely primarily on structured and adult-led approaches to teaching, including discrete trial training (DTT), which have been criticized for their intensity, limitations in skill generalization, and possible harms.
View Article and Find Full Text PDFQualitative assessment of proposed visual key information pages for informed consent.
J Clin Transl Sci
November 2024
Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Introduction: The 2018 Common Rule revision intended to improve informed consent by recommending a concise key information (KI) section, yet provided little guidance about how to describe KI. We developed innovative, visual KI templates with attention to health literacy and visual design principles. We explored end users' attitudes, beliefs, and institutional policies that could affect implementing visual KI pages.
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